Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACS38182.1 | glnE | MexAM1_META1p0220 | MexAM1_META1p0219 | Conserved hypothetical protein with ''Winged helix'' DNA-binding domain; Homologs of previously reported genes of unknown function. | Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] | 0.519 |
| ACS39663.1 | glnE | MexAM1_META1p1821 | MexAM1_META1p0219 | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] | 0.467 |
| ACS39663.1 | gltB | MexAM1_META1p1821 | MexAM1_META1p3477 | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Glutamate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.435 |
| ACS40936.1 | glnE | MexAM1_META1p3189 | MexAM1_META1p0219 | Putative thiol peroxidase, putative peroxiredoxin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] | 0.702 |
| fae | fae-2 | MexAM1_META1p1339 | MexAM1_META1p1766 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | 0.922 |
| fae | fae-3 | MexAM1_META1p1339 | MexAM1_META1p3356 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | 0.915 |
| fae | glnE | MexAM1_META1p1339 | MexAM1_META1p0219 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] | 0.448 |
| fae-2 | fae | MexAM1_META1p1766 | MexAM1_META1p1339 | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | 0.922 |
| fae-2 | fae-3 | MexAM1_META1p1766 | MexAM1_META1p3356 | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | 0.925 |
| fae-2 | glnE | MexAM1_META1p1766 | MexAM1_META1p0219 | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] | 0.660 |
| fae-3 | fae | MexAM1_META1p3356 | MexAM1_META1p1339 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | 0.915 |
| fae-3 | fae-2 | MexAM1_META1p3356 | MexAM1_META1p1766 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | 0.925 |
| fae-3 | glnE | MexAM1_META1p3356 | MexAM1_META1p0219 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] | 0.448 |
| glnA | glnB | MexAM1_META1p2379 | MexAM1_META1p2376 | Glutamine synthetase, type I; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Regulatory protein (P-II) for nitrogen assimilation by glutamine synthetase (ATase); Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the P(II) protein family. | 0.575 |
| glnA | glnE | MexAM1_META1p2379 | MexAM1_META1p0219 | Glutamine synthetase, type I; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] | 0.649 |
| glnA | gltB | MexAM1_META1p2379 | MexAM1_META1p3477 | Glutamine synthetase, type I; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Glutamate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.990 |
| glnB | glnA | MexAM1_META1p2376 | MexAM1_META1p2379 | Regulatory protein (P-II) for nitrogen assimilation by glutamine synthetase (ATase); Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the P(II) protein family. | Glutamine synthetase, type I; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.575 |
| glnB | glnD | MexAM1_META1p2376 | MexAM1_META1p0229 | Regulatory protein (P-II) for nitrogen assimilation by glutamine synthetase (ATase); Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the P(II) protein family. | [Protein-PII] uridylyltransferase (PII uridylyl- transferase) (Uridylyl-removing enzyme) (UTase); Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regu [...] | 0.982 |
| glnB | glnE | MexAM1_META1p2376 | MexAM1_META1p0219 | Regulatory protein (P-II) for nitrogen assimilation by glutamine synthetase (ATase); Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the P(II) protein family. | Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] | 0.453 |
| glnB | gltB | MexAM1_META1p2376 | MexAM1_META1p3477 | Regulatory protein (P-II) for nitrogen assimilation by glutamine synthetase (ATase); Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the P(II) protein family. | Glutamate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.538 |
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