node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS38270.1 | rph | MexAM1_META1p0318 | MexAM1_META1p0317 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Ribonuclease PH (RNase PH) (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.995 |
ACS40241.1 | rnr | MexAM1_META1p2462 | MexAM1_META1p2382 | 3'-5' exonuclease; Function of strongly homologous gene; enzyme. | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.880 |
ACS40241.1 | rph | MexAM1_META1p2462 | MexAM1_META1p0317 | 3'-5' exonuclease; Function of strongly homologous gene; enzyme. | Ribonuclease PH (RNase PH) (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.874 |
ACS40241.1 | rpsA | MexAM1_META1p2462 | MexAM1_META1p0055 | 3'-5' exonuclease; Function of strongly homologous gene; enzyme. | 30S ribosomal subunit protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. | 0.885 |
ACS40241.1 | rpsD | MexAM1_META1p2462 | MexAM1_META1p5190 | 3'-5' exonuclease; Function of strongly homologous gene; enzyme. | 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. | 0.825 |
dnaG | rph | MexAM1_META1p0436 | MexAM1_META1p0317 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. | Ribonuclease PH (RNase PH) (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.766 |
dnaG | rpoC | MexAM1_META1p0436 | MexAM1_META1p4406 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. | RNA polymerase, beta prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.520 |
pyrE | rne | MexAM1_META1p3406 | MexAM1_META1p3916 | Orotate phosphoribosyltransferase (OPRT) (OPRTase); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Putative ribonuclease E or G; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. | 0.666 |
pyrE | rph | MexAM1_META1p3406 | MexAM1_META1p0317 | Orotate phosphoribosyltransferase (OPRT) (OPRTase); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Ribonuclease PH (RNase PH) (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.800 |
pyrE | rpoC | MexAM1_META1p3406 | MexAM1_META1p4406 | Orotate phosphoribosyltransferase (OPRT) (OPRTase); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | RNA polymerase, beta prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.758 |
rnd | rnr | MexAM1_META1p3120 | MexAM1_META1p2382 | Ribonuclease D (RNase D); Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family. | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.882 |
rnd | rph | MexAM1_META1p3120 | MexAM1_META1p0317 | Ribonuclease D (RNase D); Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family. | Ribonuclease PH (RNase PH) (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.881 |
rnd | rpsA | MexAM1_META1p3120 | MexAM1_META1p0055 | Ribonuclease D (RNase D); Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family. | 30S ribosomal subunit protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. | 0.902 |
rnd | rpsD | MexAM1_META1p3120 | MexAM1_META1p5190 | Ribonuclease D (RNase D); Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family. | 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. | 0.825 |
rne | pyrE | MexAM1_META1p3916 | MexAM1_META1p3406 | Putative ribonuclease E or G; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. | Orotate phosphoribosyltransferase (OPRT) (OPRTase); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.666 |
rne | rph | MexAM1_META1p3916 | MexAM1_META1p0317 | Putative ribonuclease E or G; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. | Ribonuclease PH (RNase PH) (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.785 |
rne | rpoC | MexAM1_META1p3916 | MexAM1_META1p4406 | Putative ribonuclease E or G; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. | RNA polymerase, beta prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.599 |
rne | rpsA | MexAM1_META1p3916 | MexAM1_META1p0055 | Putative ribonuclease E or G; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. | 30S ribosomal subunit protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. | 0.492 |
rnr | ACS40241.1 | MexAM1_META1p2382 | MexAM1_META1p2462 | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 3'-5' exonuclease; Function of strongly homologous gene; enzyme. | 0.880 |
rnr | rnd | MexAM1_META1p2382 | MexAM1_META1p3120 | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | Ribonuclease D (RNase D); Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family. | 0.882 |