node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dfrA | ftfL | MexAM1_META1p2852 | MexAM1_META1p0329 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | 0.944 |
dfrA | gcvT | MexAM1_META1p2852 | MexAM1_META1p0622 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Function of strongly homologous gene; enzyme. | 0.946 |
dfrA | glyA | MexAM1_META1p2852 | MexAM1_META1p3384 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.929 |
dfrA | metH | MexAM1_META1p2852 | MexAM1_META1p1494 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.922 |
dfrA | purH | MexAM1_META1p2852 | MexAM1_META1p2535 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional: IMP cyclohydrolase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.954 |
dfrA | purN | MexAM1_META1p2852 | MexAM1_META1p2044 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.954 |
fch | ftfL | MexAM1_META1p1729 | MexAM1_META1p0329 | Methenyl tetrahydrofolate cyclohydrolase; Required for both C1 and C2 metabolism; Belongs to the cyclodeaminase/cyclohydrolase family. | Formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | 0.980 |
fch | gcvT | MexAM1_META1p1729 | MexAM1_META1p0622 | Methenyl tetrahydrofolate cyclohydrolase; Required for both C1 and C2 metabolism; Belongs to the cyclodeaminase/cyclohydrolase family. | Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Function of strongly homologous gene; enzyme. | 0.948 |
fch | glyA | MexAM1_META1p1729 | MexAM1_META1p3384 | Methenyl tetrahydrofolate cyclohydrolase; Required for both C1 and C2 metabolism; Belongs to the cyclodeaminase/cyclohydrolase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.691 |
fch | metH | MexAM1_META1p1729 | MexAM1_META1p1494 | Methenyl tetrahydrofolate cyclohydrolase; Required for both C1 and C2 metabolism; Belongs to the cyclodeaminase/cyclohydrolase family. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.494 |
fch | purH | MexAM1_META1p1729 | MexAM1_META1p2535 | Methenyl tetrahydrofolate cyclohydrolase; Required for both C1 and C2 metabolism; Belongs to the cyclodeaminase/cyclohydrolase family. | Bifunctional: IMP cyclohydrolase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.907 |
fch | purN | MexAM1_META1p1729 | MexAM1_META1p2044 | Methenyl tetrahydrofolate cyclohydrolase; Required for both C1 and C2 metabolism; Belongs to the cyclodeaminase/cyclohydrolase family. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.916 |
ftfL | dfrA | MexAM1_META1p0329 | MexAM1_META1p2852 | Formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.944 |
ftfL | fch | MexAM1_META1p0329 | MexAM1_META1p1729 | Formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Methenyl tetrahydrofolate cyclohydrolase; Required for both C1 and C2 metabolism; Belongs to the cyclodeaminase/cyclohydrolase family. | 0.980 |
ftfL | gcvT | MexAM1_META1p0329 | MexAM1_META1p0622 | Formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Function of strongly homologous gene; enzyme. | 0.958 |
ftfL | glyA | MexAM1_META1p0329 | MexAM1_META1p3384 | Formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.988 |
ftfL | icd | MexAM1_META1p0329 | MexAM1_META1p3354 | Formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | NADP-dependent isocitrate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.892 |
ftfL | metH | MexAM1_META1p0329 | MexAM1_META1p1494 | Formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.951 |
ftfL | purC | MexAM1_META1p0329 | MexAM1_META1p0412 | Formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole-succinocarboxamide synthetase (SAICAR synthetase); Function of strongly homologous gene; enzyme; Belongs to the SAICAR synthetase family. | 0.876 |
ftfL | purH | MexAM1_META1p0329 | MexAM1_META1p2535 | Formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional: IMP cyclohydrolase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.992 |