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thiO thiO thiG thiG thiS thiS thiE thiE soxA-2 soxA-2 ACS39408.1 ACS39408.1 soxD-2 soxD-2 ACS41955.1 ACS41955.1 soxD soxD ACS40521.1 ACS40521.1 ACS41849.1 ACS41849.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
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Experiments
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Textmining
[Homology]
Score
thiOGlycine oxidase; Function of strongly homologous gene; enzyme. (411 aa)    
Predicted Functional Partners:
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 0.999
thiS
Thiamin biosynthesis proteinsulfur carrier) ThiS; Function of strongly homologous gene; factor.
 
  
 0.936
thiE
Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
 
  
 0.902
soxA-2
Sarcosine oxidase, alpha subunit; Function of strongly homologous gene; enzyme.
 
 
 0.879
ACS39408.1
Putative Sarcosine oxidase alpha subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
 
 0.876
soxD-2
Sarcosine oxidase, delta subunit; Function of strongly homologous gene; enzyme.
 
 
 0.720
ACS41955.1
Putative alanine racemase (alr-like); Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
  
  
 0.658
soxD
Sarcosine oxidase, delta subunit; Function of strongly homologous gene; enzyme.
  
 
 0.634
ACS40521.1
Putative aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the GcvT family.
 
 
 0.605
ACS41849.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
 
 0.598
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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