STRINGSTRING
hemF hemF hemE hemE ACS39249.1 ACS39249.1 ACS38224.1 ACS38224.1 hemH hemH trmL trmL aroE aroE ACS38440.1 ACS38440.1 ACS38438.1 ACS38438.1 dhaK dhaK nadD nadD
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hemFCoproporphyrinogen III oxidase, aerobic (Coproporphyrinogenase) (Coprogen oxidase); Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (307 aa)    
Predicted Functional Partners:
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.966
ACS39249.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
 
  
 0.952
ACS38224.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
    
 0.928
hemH
Ferrochelatase (Protoheme ferro-lyase) (Heme synthetase); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
   
 0.732
trmL
Putative rRNA methylase; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.
      0.725
aroE
Putative shikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
  
 0.668
ACS38440.1
Function of strongly homologous gene; enzyme.
       0.666
ACS38438.1
Putative TonB-dependent siderophore receptor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative receptor.
       0.631
dhaK
Dihydroxyacetone kinase (Glycerone kinase); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
    0.625
nadD
Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
    0.604
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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