node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS38487.1 | ACS41355.1 | MexAM1_META1p0546 | MexAM1_META1p3644 | Putative Glutamine amidotransferase, class-I family protein (guaA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein with putative Transglutaminase-like domain; Homologs of previously reported genes of unknown function. | 0.522 |
ACS38487.1 | Permease | MexAM1_META1p0546 | MexAM1_META1p0545 | Putative Glutamine amidotransferase, class-I family protein (guaA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Permease; Function of strongly homologous gene; transporter. | 0.810 |
ACS38487.1 | argS | MexAM1_META1p0546 | MexAM1_META1p3624 | Putative Glutamine amidotransferase, class-I family protein (guaA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | 0.713 |
ACS38487.1 | gmk | MexAM1_META1p0546 | MexAM1_META1p1978 | Putative Glutamine amidotransferase, class-I family protein (guaA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | 0.609 |
ACS38487.1 | guaB | MexAM1_META1p0546 | MexAM1_META1p3145 | Putative Glutamine amidotransferase, class-I family protein (guaA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.945 |
ACS38487.1 | map | MexAM1_META1p0546 | MexAM1_META1p1039 | Putative Glutamine amidotransferase, class-I family protein (guaA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Methionine aminopeptidase (Peptidase M); Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.695 |
ACS38487.1 | map-2 | MexAM1_META1p0546 | MexAM1_META1p2197 | Putative Glutamine amidotransferase, class-I family protein (guaA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.695 |
ACS38487.1 | rplK | MexAM1_META1p0546 | MexAM1_META1p4385 | Putative Glutamine amidotransferase, class-I family protein (guaA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.761 |
ACS38487.1 | tatA | MexAM1_META1p0546 | MexAM1_META1p3627 | Putative Glutamine amidotransferase, class-I family protein (guaA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Sec-independent protein translocase protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.567 |
ACS38487.1 | tatB | MexAM1_META1p0546 | MexAM1_META1p3628 | Putative Glutamine amidotransferase, class-I family protein (guaA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Sec-independent protein translocase protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.567 |
ACS41355.1 | ACS38487.1 | MexAM1_META1p3644 | MexAM1_META1p0546 | Conserved hypothetical protein with putative Transglutaminase-like domain; Homologs of previously reported genes of unknown function. | Putative Glutamine amidotransferase, class-I family protein (guaA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.522 |
Permease | ACS38487.1 | MexAM1_META1p0545 | MexAM1_META1p0546 | Permease; Function of strongly homologous gene; transporter. | Putative Glutamine amidotransferase, class-I family protein (guaA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.810 |
argS | ACS38487.1 | MexAM1_META1p3624 | MexAM1_META1p0546 | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | Putative Glutamine amidotransferase, class-I family protein (guaA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.713 |
argS | gmk | MexAM1_META1p3624 | MexAM1_META1p1978 | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | 0.440 |
argS | guaB | MexAM1_META1p3624 | MexAM1_META1p3145 | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.601 |
argS | rplK | MexAM1_META1p3624 | MexAM1_META1p4385 | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | 50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.643 |
argS | tatA | MexAM1_META1p3624 | MexAM1_META1p3627 | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | Sec-independent protein translocase protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.435 |
gmk | ACS38487.1 | MexAM1_META1p1978 | MexAM1_META1p0546 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Putative Glutamine amidotransferase, class-I family protein (guaA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.609 |
gmk | argS | MexAM1_META1p1978 | MexAM1_META1p3624 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | 0.440 |
gmk | guaB | MexAM1_META1p1978 | MexAM1_META1p3145 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.589 |