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dme dme pdhB pdhB pyk pyk pyk-2 pyk-2 fumC fumC fumC-2 fumC-2 pdhA pdhA mdh mdh poxB poxB ppdK ppdK mqo mqo
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dmeNAD-dependent malic enzyme; Function of homologous gene experimentally demonstrated in an other organism; putative enzyme. (777 aa)    
Predicted Functional Partners:
pdhB
Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
  
 
 0.992
pyk
Pyruvate kinase; Function of strongly homologous gene; enzyme; Belongs to the pyruvate kinase family.
  
 0.988
pyk-2
Pyruvate kinase; Function of strongly homologous gene; enzyme.
  
 0.988
fumC
Fumarase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 
 0.973
fumC-2
Fumarase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 
 0.973
pdhA
Pyruvate dehydrogenase E1 alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 
 0.972
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.970
poxB
poxB; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TPP enzyme family.
  
 
 0.952
ppdK
Pyruvate phosphate dikinase (Pyruvate, orthophosphate dikinase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the PEP-utilizing enzyme family.
  
 
 0.947
mqo
Malate dehydrogenase, FAD/NAD(P)-binding domain (tat pathway signal); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.944
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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