node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS39408.1 | gcvH | MexAM1_META1p1546 | MexAM1_META1p0621 | Putative Sarcosine oxidase alpha subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.982 |
ACS39408.1 | gcvP | MexAM1_META1p1546 | MexAM1_META1p0620 | Putative Sarcosine oxidase alpha subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.973 |
ACS39408.1 | gcvT | MexAM1_META1p1546 | MexAM1_META1p0622 | Putative Sarcosine oxidase alpha subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Function of strongly homologous gene; enzyme. | 0.533 |
ACS39408.1 | glyA | MexAM1_META1p1546 | MexAM1_META1p3384 | Putative Sarcosine oxidase alpha subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.778 |
ACS39408.1 | lpd | MexAM1_META1p1546 | MexAM1_META1p1542 | Putative Sarcosine oxidase alpha subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Dihydrolipoyl dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.748 |
ACS39408.1 | lpd-2 | MexAM1_META1p1546 | MexAM1_META1p2990 | Putative Sarcosine oxidase alpha subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Dihydrolipoamide dehydrogenase, E3 Component of Pyruvate dehydrogenase multienzyme complex; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.748 |
ACS39408.1 | soxG-2 | MexAM1_META1p1546 | MexAM1_META1p4111 | Putative Sarcosine oxidase alpha subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Sarcosine oxidase, gamma subunit; Function of strongly homologous gene; enzyme. | 0.965 |
gcvH | ACS39408.1 | MexAM1_META1p0621 | MexAM1_META1p1546 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Putative Sarcosine oxidase alpha subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.982 |
gcvH | gcvP | MexAM1_META1p0621 | MexAM1_META1p0620 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH | gcvT | MexAM1_META1p0621 | MexAM1_META1p0622 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Function of strongly homologous gene; enzyme. | 0.999 |
gcvH | glyA | MexAM1_META1p0621 | MexAM1_META1p3384 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.991 |
gcvH | lpd | MexAM1_META1p0621 | MexAM1_META1p1542 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Dihydrolipoyl dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.978 |
gcvH | lpd-2 | MexAM1_META1p0621 | MexAM1_META1p2990 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Dihydrolipoamide dehydrogenase, E3 Component of Pyruvate dehydrogenase multienzyme complex; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.975 |
gcvH | sga | MexAM1_META1p0621 | MexAM1_META1p1726 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine-glyoxylate aminotransferase (SGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. | 0.919 |
gcvH | sga-2 | MexAM1_META1p0621 | MexAM1_META1p4592 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine-glyoxylate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.919 |
gcvH | soxA-2 | MexAM1_META1p0621 | MexAM1_META1p4110 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Sarcosine oxidase, alpha subunit; Function of strongly homologous gene; enzyme. | 0.969 |
gcvP | ACS39408.1 | MexAM1_META1p0620 | MexAM1_META1p1546 | Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Putative Sarcosine oxidase alpha subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.973 |
gcvP | gcvH | MexAM1_META1p0620 | MexAM1_META1p0621 | Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
gcvP | gcvT | MexAM1_META1p0620 | MexAM1_META1p0622 | Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Function of strongly homologous gene; enzyme. | 0.999 |
gcvP | glyA | MexAM1_META1p0620 | MexAM1_META1p3384 | Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |