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purA purA purB purB guaB guaB purH purH guaA guaA pyrB pyrB hpt hpt argG argG surE surE ACS42926.1 ACS42926.1 ACS40589.1 ACS40589.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (448 aa)    
Predicted Functional Partners:
purB
Adenylosuccinate lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 0.998
guaB
IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.996
purH
Bifunctional: IMP cyclohydrolase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 0.991
guaA
GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP.
 
  
 0.955
pyrB
Aspartate carbamoyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
 
 0.952
hpt
Hypoxanthine phosphoribosyl transferase; Function of strongly homologous gene; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.939
argG
Argininosuccinate synthase (citrulline-aspartate ligase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  
 
 0.933
surE
5'-nucleotidase surE (Nucleoside 5'-monophosphate phosphohydrolase); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.927
ACS42926.1
Putative asparagine synthase, glutamine-hydrolyzing; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
 0.927
ACS40589.1
Putative L-aspartate oxidase (nadB-like); Catalyzes the oxidation of L-aspartate to iminoaspartate.
     
 0.920
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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