node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS41747.1 | ecm | MexAM1_META1p4094 | MexAM1_META1p0180 | ATP-dependent urea carboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | 0.574 |
ACS41747.1 | epi | MexAM1_META1p4094 | MexAM1_META1p0839 | ATP-dependent urea carboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.701 |
ACS41747.1 | mcmA | MexAM1_META1p4094 | MexAM1_META1p5251 | ATP-dependent urea carboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.574 |
ACS41747.1 | mdcE | MexAM1_META1p4094 | MexAM1_META1p0026 | ATP-dependent urea carboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Malonate decarboxylase, gamma subunit; Function of strongly homologous gene; enzyme. | 0.977 |
ACS41747.1 | pccA | MexAM1_META1p4094 | MexAM1_META1p3203 | ATP-dependent urea carboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | propionyl-CoA carboxylase alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.944 |
ACS41747.1 | pccB | MexAM1_META1p4094 | MexAM1_META1p0172 | ATP-dependent urea carboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | propionyl-CoA carboxylase beta chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.985 |
ccr | ecm | MexAM1_META1p0178 | MexAM1_META1p0180 | crotonyl-CoA carboxylase/reductase; Function experimentally demonstrated in the studied strain; enzyme. | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | 0.957 |
ccr | epi | MexAM1_META1p0178 | MexAM1_META1p0839 | crotonyl-CoA carboxylase/reductase; Function experimentally demonstrated in the studied strain; enzyme. | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.966 |
ecm | ACS41747.1 | MexAM1_META1p0180 | MexAM1_META1p4094 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | ATP-dependent urea carboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.574 |
ecm | ccr | MexAM1_META1p0180 | MexAM1_META1p0178 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | crotonyl-CoA carboxylase/reductase; Function experimentally demonstrated in the studied strain; enzyme. | 0.957 |
ecm | epi | MexAM1_META1p0180 | MexAM1_META1p0839 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.995 |
ecm | mcmA | MexAM1_META1p0180 | MexAM1_META1p5251 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.978 |
ecm | mcmB | MexAM1_META1p0180 | MexAM1_META1p2390 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | methylmalonyl-CoA beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.982 |
ecm | mdcE | MexAM1_META1p0180 | MexAM1_META1p0026 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | Malonate decarboxylase, gamma subunit; Function of strongly homologous gene; enzyme. | 0.470 |
ecm | meaB | MexAM1_META1p0180 | MexAM1_META1p0188 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | methylmalonyl-CoA mutase accessory protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.997 |
ecm | pccA | MexAM1_META1p0180 | MexAM1_META1p3203 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | propionyl-CoA carboxylase alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.485 |
ecm | pccB | MexAM1_META1p0180 | MexAM1_META1p0172 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | propionyl-CoA carboxylase beta chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.886 |
epi | ACS41747.1 | MexAM1_META1p0839 | MexAM1_META1p4094 | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | ATP-dependent urea carboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.701 |
epi | ccr | MexAM1_META1p0839 | MexAM1_META1p0178 | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | crotonyl-CoA carboxylase/reductase; Function experimentally demonstrated in the studied strain; enzyme. | 0.966 |
epi | ecm | MexAM1_META1p0839 | MexAM1_META1p0180 | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | 0.995 |