STRINGSTRING
epi epi ecm ecm pccB pccB mcmA mcmA mcmB mcmB ccr ccr pccA pccA meaB meaB matB matB mdcE mdcE ACS41747.1 ACS41747.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
epiethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (134 aa)    
Predicted Functional Partners:
ecm
ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate.
 
  
 0.995
pccB
propionyl-CoA carboxylase beta chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
 0.994
mcmA
methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.987
mcmB
methylmalonyl-CoA beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.976
ccr
crotonyl-CoA carboxylase/reductase; Function experimentally demonstrated in the studied strain; enzyme.
     
 0.966
pccA
propionyl-CoA carboxylase alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.951
meaB
methylmalonyl-CoA mutase accessory protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 0.935
matB
Malonyl CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.901
mdcE
Malonate decarboxylase, gamma subunit; Function of strongly homologous gene; enzyme.
  
  
 0.830
ACS41747.1
ATP-dependent urea carboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
  
 0.701
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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