node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS40481.1 | nrd | MexAM1_META1p2716 | MexAM1_META1p0872 | Conserved hypothetical protein, UPF0301 protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent, large subunit; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.988 |
ACS40481.1 | thyA | MexAM1_META1p2716 | MexAM1_META1p2853 | Conserved hypothetical protein, UPF0301 protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.762 |
adk | gmk | MexAM1_META1p2171 | MexAM1_META1p1978 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | 0.705 |
adk | nrd | MexAM1_META1p2171 | MexAM1_META1p0872 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent, large subunit; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.920 |
adk | pyk | MexAM1_META1p2171 | MexAM1_META1p2749 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Pyruvate kinase; Function of strongly homologous gene; enzyme; Belongs to the pyruvate kinase family. | 0.919 |
adk | pyk-2 | MexAM1_META1p2171 | MexAM1_META1p2941 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Pyruvate kinase; Function of strongly homologous gene; enzyme. | 0.919 |
adk | tmk | MexAM1_META1p2171 | MexAM1_META1p4582 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.407 |
cmk | gmk | MexAM1_META1p2119 | MexAM1_META1p1978 | Cytidine monophosphate (CMP) kinase; Function of strongly homologous gene; enzyme. | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | 0.650 |
cmk | nrd | MexAM1_META1p2119 | MexAM1_META1p0872 | Cytidine monophosphate (CMP) kinase; Function of strongly homologous gene; enzyme. | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent, large subunit; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.927 |
gmk | adk | MexAM1_META1p1978 | MexAM1_META1p2171 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.705 |
gmk | cmk | MexAM1_META1p1978 | MexAM1_META1p2119 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Cytidine monophosphate (CMP) kinase; Function of strongly homologous gene; enzyme. | 0.650 |
gmk | nrd | MexAM1_META1p1978 | MexAM1_META1p0872 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent, large subunit; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.920 |
gmk | pyk | MexAM1_META1p1978 | MexAM1_META1p2749 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Pyruvate kinase; Function of strongly homologous gene; enzyme; Belongs to the pyruvate kinase family. | 0.924 |
gmk | pyk-2 | MexAM1_META1p1978 | MexAM1_META1p2941 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Pyruvate kinase; Function of strongly homologous gene; enzyme. | 0.924 |
gmk | relA | MexAM1_META1p1978 | MexAM1_META1p3408 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.929 |
gmk | thyA | MexAM1_META1p1978 | MexAM1_META1p2853 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.808 |
gmk | tmk | MexAM1_META1p1978 | MexAM1_META1p4582 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.420 |
grxC | nrd | MexAM1_META1p3489 | MexAM1_META1p0872 | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent, large subunit; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.982 |
nrd | ACS40481.1 | MexAM1_META1p0872 | MexAM1_META1p2716 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent, large subunit; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Conserved hypothetical protein, UPF0301 protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. | 0.988 |
nrd | adk | MexAM1_META1p0872 | MexAM1_META1p2171 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent, large subunit; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.920 |