node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS39236.1 | ACS39237.1 | MexAM1_META1p1374 | MexAM1_META1p1375 | Conserved hypothetical protein with 4'-phosphopantetheinyl transferase domain; Homologs of previously reported genes of unknown function; Belongs to the P-Pant transferase superfamily. | Putative hydrolase, Nudix domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.773 |
ACS39236.1 | ampC | MexAM1_META1p1374 | MexAM1_META1p1373 | Conserved hypothetical protein with 4'-phosphopantetheinyl transferase domain; Homologs of previously reported genes of unknown function; Belongs to the P-Pant transferase superfamily. | beta-lactamase/D-ala carboxypeptidase; Function of strongly homologous gene; enzyme. | 0.520 |
ACS39237.1 | ACS39236.1 | MexAM1_META1p1375 | MexAM1_META1p1374 | Putative hydrolase, Nudix domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein with 4'-phosphopantetheinyl transferase domain; Homologs of previously reported genes of unknown function; Belongs to the P-Pant transferase superfamily. | 0.773 |
ACS39237.1 | ampC | MexAM1_META1p1375 | MexAM1_META1p1373 | Putative hydrolase, Nudix domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | beta-lactamase/D-ala carboxypeptidase; Function of strongly homologous gene; enzyme. | 0.520 |
ampC | ACS39236.1 | MexAM1_META1p1373 | MexAM1_META1p1374 | beta-lactamase/D-ala carboxypeptidase; Function of strongly homologous gene; enzyme. | Conserved hypothetical protein with 4'-phosphopantetheinyl transferase domain; Homologs of previously reported genes of unknown function; Belongs to the P-Pant transferase superfamily. | 0.520 |
ampC | ACS39237.1 | MexAM1_META1p1373 | MexAM1_META1p1375 | beta-lactamase/D-ala carboxypeptidase; Function of strongly homologous gene; enzyme. | Putative hydrolase, Nudix domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.520 |
ampC | folP | MexAM1_META1p1373 | MexAM1_META1p1745 | beta-lactamase/D-ala carboxypeptidase; Function of strongly homologous gene; enzyme. | 7,8-dihydropteroate synthase (dihydropteroate synthase (DHPS), dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.695 |
ampC | gyrA | MexAM1_META1p1373 | MexAM1_META1p5016 | beta-lactamase/D-ala carboxypeptidase; Function of strongly homologous gene; enzyme. | DNA gyrase, subunit A (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] | 0.690 |
ampC | gyrB | MexAM1_META1p1373 | MexAM1_META1p2546 | beta-lactamase/D-ala carboxypeptidase; Function of strongly homologous gene; enzyme. | DNA gyrase, subunit B (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] | 0.495 |
ampC | murA | MexAM1_META1p1373 | MexAM1_META1p1964 | beta-lactamase/D-ala carboxypeptidase; Function of strongly homologous gene; enzyme. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.699 |
ampC | parC | MexAM1_META1p1373 | MexAM1_META1p0822 | beta-lactamase/D-ala carboxypeptidase; Function of strongly homologous gene; enzyme. | DNA topoisomerase IV subunitA; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.478 |
ampC | parE | MexAM1_META1p1373 | MexAM1_META1p3331 | beta-lactamase/D-ala carboxypeptidase; Function of strongly homologous gene; enzyme. | DNA topoisomerase IV, subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | 0.495 |
ampC | pgm | MexAM1_META1p1373 | MexAM1_META1p3093 | beta-lactamase/D-ala carboxypeptidase; Function of strongly homologous gene; enzyme. | Phosphoglucomutase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.464 |
ampC | sugE | MexAM1_META1p1373 | MexAM1_META1p1284 | beta-lactamase/D-ala carboxypeptidase; Function of strongly homologous gene; enzyme. | Multidrug efflux system protein; Function of homologous gene experimentally demonstrated in an other organism; transporter. | 0.669 |
folP | ampC | MexAM1_META1p1745 | MexAM1_META1p1373 | 7,8-dihydropteroate synthase (dihydropteroate synthase (DHPS), dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | beta-lactamase/D-ala carboxypeptidase; Function of strongly homologous gene; enzyme. | 0.695 |
folP | gyrA | MexAM1_META1p1745 | MexAM1_META1p5016 | 7,8-dihydropteroate synthase (dihydropteroate synthase (DHPS), dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | DNA gyrase, subunit A (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] | 0.442 |
folP | pgm | MexAM1_META1p1745 | MexAM1_META1p3093 | 7,8-dihydropteroate synthase (dihydropteroate synthase (DHPS), dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Phosphoglucomutase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.690 |
gyrA | ampC | MexAM1_META1p5016 | MexAM1_META1p1373 | DNA gyrase, subunit A (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] | beta-lactamase/D-ala carboxypeptidase; Function of strongly homologous gene; enzyme. | 0.690 |
gyrA | folP | MexAM1_META1p5016 | MexAM1_META1p1745 | DNA gyrase, subunit A (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] | 7,8-dihydropteroate synthase (dihydropteroate synthase (DHPS), dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.442 |
gyrA | gyrB | MexAM1_META1p5016 | MexAM1_META1p2546 | DNA gyrase, subunit A (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] | DNA gyrase, subunit B (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] | 0.998 |