STRINGSTRING
dnaQ dnaQ dnaN dnaN dnaE dnaE dnaX dnaX holB holB ACS39340.1 ACS39340.1 ACS42709.1 ACS42709.1 rnhA rnhA ACS38179.1 ACS38179.1 coaE coaE dnaE-2 dnaE-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaQDNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (236 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 0.981
dnaE
DNA polymerase III, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 0.972
dnaX
DNA polymerase III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
   
 0.972
holB
DNA polymerase III, delta prime subunit; Function of strongly homologous gene; putative enzyme.
   
 0.971
ACS39340.1
Putative DNA polymerase III, delta subunit, holA; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
    
 0.956
ACS42709.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
   
 0.935
rnhA
Ribonuclease H (RNase H); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
 
  
 0.930
ACS38179.1
Hypothetical protein, putative exonuclease domain; No homology to any previously reported sequences.
     
 
0.900
coaE
dephospho-CoA kinase (dephosphocoenzyme A kinase); Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
   
 0.830
dnaE-2
Error-prone DNA polymerase, DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.
   
 
 0.733
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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