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hemE hemE hemC hemC hemF hemF hemH hemH cysG cysG ACS38498.1 ACS38498.1 ACS39249.1 ACS39249.1 hemB hemB ACS39248.1 ACS39248.1 trmU trmU hppa hppa
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (360 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.977
hemF
Coproporphyrinogen III oxidase, aerobic (Coproporphyrinogenase) (Coprogen oxidase); Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX.
 
 0.966
hemH
Ferrochelatase (Protoheme ferro-lyase) (Heme synthetase); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.957
cysG
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
    
 0.950
ACS38498.1
Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.937
ACS39249.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
 
   
 0.907
hemB
Porphobilinogen synthase; Function of strongly homologous gene; enzyme; Belongs to the ALAD family.
 
 
 0.816
ACS39248.1
Putative Nudix hydrolase family protein, putative pyrophosphohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
    0.777
trmU
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
      
 0.737
hppa
H+ translocating pyrophosphate synthase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.
      
 0.730
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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