node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS39252.1 | hisA | MexAM1_META1p1390 | MexAM1_META1p2518 | Putative histidyl-tRNA synthetase (hisS); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of strongly homologous gene; enzyme. | 0.905 |
ACS39252.1 | hisB | MexAM1_META1p1390 | MexAM1_META1p2515 | Putative histidyl-tRNA synthetase (hisS); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Imidazoleglycerol-phosphate dehydratase; Function of strongly homologous gene; enzyme. | 0.899 |
ACS39252.1 | hisC | MexAM1_META1p1390 | MexAM1_META1p1486 | Putative histidyl-tRNA synthetase (hisS); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Histidinol-phosphate aminotransferase; Function of strongly homologous gene; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.867 |
ACS39252.1 | hisD | MexAM1_META1p1390 | MexAM1_META1p1961 | Putative histidyl-tRNA synthetase (hisS); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Bifunctional HisD: L-histidinal:NAD+ dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.910 |
ACS39252.1 | hisE | MexAM1_META1p1390 | MexAM1_META1p2520 | Putative histidyl-tRNA synthetase (hisS); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | phosphoribosyl-ATP pyrophosphatase; Function of strongly homologous gene; enzyme. | 0.989 |
ACS39252.1 | hisF | MexAM1_META1p1390 | MexAM1_META1p2519 | Putative histidyl-tRNA synthetase (hisS); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Imidazole glycerol phosphate synthase, subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.911 |
ACS39252.1 | hisG | MexAM1_META1p1390 | MexAM1_META1p1389 | Putative histidyl-tRNA synthetase (hisS); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
ACS39252.1 | hisH | MexAM1_META1p1390 | MexAM1_META1p2517 | Putative histidyl-tRNA synthetase (hisS); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Glutamine amidotransferase, subunit with HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.889 |
ACS39252.1 | hisI | MexAM1_META1p1390 | MexAM1_META1p2263 | Putative histidyl-tRNA synthetase (hisS); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.905 |
ACS39252.1 | hisS | MexAM1_META1p1390 | MexAM1_META1p1446 | Putative histidyl-tRNA synthetase (hisS); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | histidyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | 0.818 |
hisA | ACS39252.1 | MexAM1_META1p2518 | MexAM1_META1p1390 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of strongly homologous gene; enzyme. | Putative histidyl-tRNA synthetase (hisS); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.905 |
hisA | hisB | MexAM1_META1p2518 | MexAM1_META1p2515 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of strongly homologous gene; enzyme. | Imidazoleglycerol-phosphate dehydratase; Function of strongly homologous gene; enzyme. | 0.991 |
hisA | hisC | MexAM1_META1p2518 | MexAM1_META1p1486 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of strongly homologous gene; enzyme. | Histidinol-phosphate aminotransferase; Function of strongly homologous gene; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.919 |
hisA | hisD | MexAM1_META1p2518 | MexAM1_META1p1961 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of strongly homologous gene; enzyme. | Bifunctional HisD: L-histidinal:NAD+ dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.976 |
hisA | hisE | MexAM1_META1p2518 | MexAM1_META1p2520 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of strongly homologous gene; enzyme. | phosphoribosyl-ATP pyrophosphatase; Function of strongly homologous gene; enzyme. | 0.985 |
hisA | hisF | MexAM1_META1p2518 | MexAM1_META1p2519 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of strongly homologous gene; enzyme. | Imidazole glycerol phosphate synthase, subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.997 |
hisA | hisG | MexAM1_META1p2518 | MexAM1_META1p1389 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of strongly homologous gene; enzyme. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.967 |
hisA | hisH | MexAM1_META1p2518 | MexAM1_META1p2517 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of strongly homologous gene; enzyme. | Glutamine amidotransferase, subunit with HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | MexAM1_META1p2518 | MexAM1_META1p2263 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of strongly homologous gene; enzyme. | Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | ACS39252.1 | MexAM1_META1p2515 | MexAM1_META1p1390 | Imidazoleglycerol-phosphate dehydratase; Function of strongly homologous gene; enzyme. | Putative histidyl-tRNA synthetase (hisS); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.899 |