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meaD meaD btuR btuR cobS cobS cobP cobP cobQ cobQ cobC cobC ACS39192.1 ACS39192.1 cobB cobB cobD cobD ACS42177.1 ACS42177.1 cobT-2 cobT-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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meaDCobalamin adenosyltransferase, methylmalonyl-CoA mutase cofactor biosynthesis protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa)    
Predicted Functional Partners:
btuR
cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.
    
 0.932
cobS
Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
    
 0.931
cobP
Bifunctional adenosylcobalamin biosynthesis protein cobP; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.
    
 0.930
cobQ
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
  
 
 0.928
cobC
Threonine-phosphate decarboxylase (L-threonine-O-3- phosphate decarboxylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
    
 0.926
ACS39192.1
Putative cobaltochelatase, CobN subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
    
 0.924
cobB
Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
    
 0.923
cobD
Cobalamin biosynthesis protein cobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
    
 0.923
ACS42177.1
Conserved hypothetical protein, DUF336; Homologs of previously reported genes of unknown function.
     0.921
cobT-2
Cobaltochelatase (cobT protein); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
    
  0.900
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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