STRINGSTRING
hisC hisC hisB hisB ACS39347.1 ACS39347.1 hisD hisD hisH hisH hisG hisG hisF hisF ACS38194.1 ACS38194.1 hisI hisI aatA aatA ACS40467.1 ACS40467.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
hisCHistidinol-phosphate aminotransferase; Function of strongly homologous gene; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (372 aa)    
Predicted Functional Partners:
hisB
Imidazoleglycerol-phosphate dehydratase; Function of strongly homologous gene; enzyme.
 
 0.999
ACS39347.1
Putative cyclohexadienyl dehydrogenase (tyrC-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
 
 0.998
hisD
Bifunctional HisD: L-histidinal:NAD+ dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.991
hisH
Glutamine amidotransferase, subunit with HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.950
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.938
hisF
Imidazole glycerol phosphate synthase, subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.931
ACS38194.1
Putative Prephenate dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
 0.929
hisI
Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.929
aatA
Aspartate aminotransferase A; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
0.922
ACS40467.1
Aspartate transaminase; Function of strongly homologous gene; enzyme.
 
 
0.920
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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