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metH metH metF metF ACS40808.1 ACS40808.1 metC metC ahcY ahcY ftfL ftfL metK metK hom hom gcvT gcvT metY metY metY-2 metY-2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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metHB12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1250 aa)    
Predicted Functional Partners:
metF
5,10-methylenetetrahydrofolate reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.997
ACS40808.1
Putative cystathionine gamma-synthase, PLP-dependent (metB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
  
 
 0.986
metC
Cystathionine beta-lyase, PLP-dependent (beta-cystathionase); Function of strongly homologous gene; enzyme.
  
 
 0.986
ahcY
S-adenosyl L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.952
ftfL
Formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family.
  
 
 0.951
metK
Methionine adenosyltransferase 1 (AdoMet synthetase); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.951
hom
Homoserine dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.949
gcvT
Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Function of strongly homologous gene; enzyme.
  
 
 0.948
metY
Trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.946
metY-2
Trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase); Function of strongly homologous gene; enzyme.
  
 
 0.946
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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