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moeB moeB moaD moaD iscS iscS thiG thiG thiS thiS moaE moaE thiC thiC thiD thiD mobB mobB thiE thiE sdhB sdhB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
moeBMolybdopterin synthase sulfurylase; Function of strongly homologous gene; enzyme. (275 aa)    
Predicted Functional Partners:
moaD
Molybdopterin converting factor, subunit 1; Function of strongly homologous gene; enzyme.
  
 0.979
iscS
Cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent; Function of strongly homologous gene; enzyme.
   
 0.964
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 0.957
thiS
Thiamin biosynthesis proteinsulfur carrier) ThiS; Function of strongly homologous gene; factor.
  
 
 0.945
moaE
Molybdopterin synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.937
thiC
Thiamine biosynthesis protein thiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
  
 0.885
thiD
Bifunctional: hydroxy-methylpyrimidine kinase (HMP kinase); Function of strongly homologous gene; enzyme.
  
 0.808
mobB
Molybdopterin-guanine dinucleotide biosynthesis protein B, GTP-binding; Function of strongly homologous gene; enzyme.
 
  
 0.755
thiE
Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
 
  
 0.740
sdhB
Succinate dehydrogenase, iron-sulfur subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
      0.719
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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