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mdh mdh gltA gltA fumC fumC fumC-2 fumC-2 mtkB mtkB icd icd mtkA mtkA dme dme mqo mqo pck pck gapA gapA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)    
Predicted Functional Partners:
gltA
Citrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family.
  
 0.996
fumC
Fumarase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.989
fumC-2
Fumarase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.989
mtkB
Malate thiokinase, small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 0.981
icd
NADP-dependent isocitrate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 
 0.976
mtkA
Malate thiokinase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the succinate/malate CoA ligase beta subunit family.
  
 0.974
dme
NAD-dependent malic enzyme; Function of homologous gene experimentally demonstrated in an other organism; putative enzyme.
  
 0.970
mqo
Malate dehydrogenase, FAD/NAD(P)-binding domain (tat pathway signal); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
    
 0.939
pck
Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
 
 
 0.937
gapA
Glyceraldehyde-3-phosphate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
  
 
 0.931
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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