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rutD rutD rutB rutB rutC rutC rutA rutA rutF rutF ACS39663.1 ACS39663.1 ACS39206.1 ACS39206.1 ACS38243.1 ACS38243.1 acpP acpP ACS39514.1 ACS39514.1 rutF-2 rutF-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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rutDPutative enzyme of alternative pyrimidine degradation pathway, putative alpha/beta hydrolase; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. Belongs to the AB hydrolase superfamily. Hydrolase RutD family. (260 aa)    
Predicted Functional Partners:
rutB
Enzyme of alternative pyrimidine degradation pathway; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2; Belongs to the isochorismatase family. RutB subfamily.
 
 0.993
rutC
Enzyme of alternative pyrimidine degradation pathway; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation.
 
 
 0.990
rutA
Putative luciferase family protein, putative flavin-dependent oxidoreductase; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate.
 
  
 0.937
rutF
Flavin reductase domain protein, FMN-binding; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway; Belongs to the non-flavoprotein flavin reductase family. RutF subfamily.
 
  
 0.845
ACS39663.1
Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
 0.785
ACS39206.1
Putative alpha/beta hydrolase, putative epoxide hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
   
 0.710
ACS38243.1
Putative alpha/beta hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
   
 0.696
acpP
Acyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis.
   
   0.684
ACS39514.1
Putative transcriptional regulator, TetR/AcrR family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator.
 
     0.577
rutF-2
flavin:NADH oxidoreductase, putative alternative pyrimidine degradation enzyme; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway; Belongs to the non-flavoprotein flavin reductase family. RutF subfamily.
 
  
 0.537
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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