STRINGSTRING
panB panB panC panC panE panE ACS40889.1 ACS40889.1 ilvE ilvE ACS42657.1 ACS42657.1 ilvD-2 ilvD-2 ilvD ilvD ACS41918.1 ACS41918.1 guaA guaA folK folK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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panB3-methyl-2-oxobutanoate hydroxymethyltransferase, pantothenate biosynthetic process; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (274 aa)    
Predicted Functional Partners:
panC
Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
 0.998
panE
2-dehydropantoate 2-reductase (ketopantoate reductase); Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
    
 0.928
ACS40889.1
Conserved hypothetical protein, putative domain: Ketopantoate reductase ApbA/PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
    
 0.928
ilvE
Putative branched-chain amino acid transferase (ilvE-like); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
    
 0.920
ACS42657.1
Putative branched-chain amino acid aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
    
 0.920
ilvD-2
Putative dihydroxyacid dehydratase (ilvD-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the IlvD/Edd family.
     
 0.919
ilvD
Dihydroxyacid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family.
     
 0.919
ACS41918.1
Putative branched-chain amino acid aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
    
 0.917
guaA
GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP.
     
 0.793
folK
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the HPPK family.
 
  
 0.768
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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