STRINGSTRING
fch fch mtdA mtdA ftfL ftfL gcvT gcvT ACS40147.1 ACS40147.1 ACS41473.1 ACS41473.1 purN purN ACS38751.1 ACS38751.1 fmt fmt ACS40286.1 ACS40286.1 purH purH
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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fchMethenyl tetrahydrofolate cyclohydrolase; Required for both C1 and C2 metabolism; Belongs to the cyclodeaminase/cyclohydrolase family. (208 aa)    
Predicted Functional Partners:
mtdA
NADP-dependent methylene-tetrahydromethanopterin/methylene- tetrahydrofolate dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT. Can also catalyze the reversible dehydrogenation of methylene-H(4)F with 20-fold lower catalytic efficiency.
 
  
 0.992
ftfL
Formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family.
 
  
 0.980
gcvT
Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Function of strongly homologous gene; enzyme.
  
 
 0.948
ACS40147.1
Putative ligase (ygfA); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
    
 0.926
ACS41473.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
    
 0.926
purN
Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
     
 0.916
ACS38751.1
Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
    
 0.910
fmt
10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
    
 0.910
ACS40286.1
Putative Methionyl-tRNA formyltransferase (partial); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
    
 0.910
purH
Bifunctional: IMP cyclohydrolase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
    
 0.907
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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