node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS41931.1 | ACS42486.1 | MexAM1_META1p4295 | MexAM1_META1p4877 | Putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the HpcH/HpaI aldolase family. | Putative acetyl-coenzyme A synthetase (acsA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.904 |
ACS41931.1 | acs | MexAM1_META1p4295 | MexAM1_META1p2531 | Putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the HpcH/HpaI aldolase family. | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.904 |
ACS41931.1 | mcl | MexAM1_META1p4295 | MexAM1_META1p1733 | Putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the HpcH/HpaI aldolase family. | malyl-CoA lyase/beta-methylmalyl-CoA lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the HpcH/HpaI aldolase family. | 0.915 |
ACS41931.1 | mtkA | MexAM1_META1p4295 | MexAM1_META1p1730 | Putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the HpcH/HpaI aldolase family. | Malate thiokinase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the succinate/malate CoA ligase beta subunit family. | 0.913 |
ACS41931.1 | mtkB | MexAM1_META1p4295 | MexAM1_META1p1731 | Putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the HpcH/HpaI aldolase family. | Malate thiokinase, small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.946 |
ACS42486.1 | ACS41931.1 | MexAM1_META1p4877 | MexAM1_META1p4295 | Putative acetyl-coenzyme A synthetase (acsA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the HpcH/HpaI aldolase family. | 0.904 |
ACS42486.1 | acs | MexAM1_META1p4877 | MexAM1_META1p2531 | Putative acetyl-coenzyme A synthetase (acsA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.932 |
ACS42486.1 | mcl | MexAM1_META1p4877 | MexAM1_META1p1733 | Putative acetyl-coenzyme A synthetase (acsA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | malyl-CoA lyase/beta-methylmalyl-CoA lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the HpcH/HpaI aldolase family. | 0.907 |
ACS42486.1 | mdh | MexAM1_META1p4877 | MexAM1_META1p1537 | Putative acetyl-coenzyme A synthetase (acsA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.438 |
ACS42486.1 | mtkA | MexAM1_META1p4877 | MexAM1_META1p1730 | Putative acetyl-coenzyme A synthetase (acsA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Malate thiokinase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the succinate/malate CoA ligase beta subunit family. | 0.915 |
ACS42486.1 | mtkB | MexAM1_META1p4877 | MexAM1_META1p1731 | Putative acetyl-coenzyme A synthetase (acsA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Malate thiokinase, small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.911 |
ACS42486.1 | sucC | MexAM1_META1p4877 | MexAM1_META1p1538 | Putative acetyl-coenzyme A synthetase (acsA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.830 |
acs | ACS41931.1 | MexAM1_META1p2531 | MexAM1_META1p4295 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the HpcH/HpaI aldolase family. | 0.904 |
acs | ACS42486.1 | MexAM1_META1p2531 | MexAM1_META1p4877 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Putative acetyl-coenzyme A synthetase (acsA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.932 |
acs | mcl | MexAM1_META1p2531 | MexAM1_META1p1733 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | malyl-CoA lyase/beta-methylmalyl-CoA lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the HpcH/HpaI aldolase family. | 0.904 |
acs | mtkA | MexAM1_META1p2531 | MexAM1_META1p1730 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Malate thiokinase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the succinate/malate CoA ligase beta subunit family. | 0.915 |
acs | mtkB | MexAM1_META1p2531 | MexAM1_META1p1731 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Malate thiokinase, small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.911 |
acs | sucC | MexAM1_META1p2531 | MexAM1_META1p1538 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.830 |
fumC | fumC-2 | MexAM1_META1p1338 | MexAM1_META1p2857 | Fumarase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Fumarase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.903 |
fumC | mdh | MexAM1_META1p1338 | MexAM1_META1p1537 | Fumarase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.989 |