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mcl mcl mtkB mtkB mtkA mtkA meaC meaC sga sga sga-2 sga-2 hprA hprA ACS38288.1 ACS38288.1 pccA pccA ACS41931.1 ACS41931.1 pccB pccB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
mclmalyl-CoA lyase/beta-methylmalyl-CoA lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the HpcH/HpaI aldolase family. (324 aa)    
Predicted Functional Partners:
mtkB
Malate thiokinase, small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.976
mtkA
Malate thiokinase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the succinate/malate CoA ligase beta subunit family.
    
 0.973
meaC
Mesaconyl-CoA hydratase; Part of the glyoxylate regeneration cycle that is essential for growth on C1 and C2 compounds; Function experimentally demonstrated in the studied strain; enzyme.
 
 
 0.966
sga
Serine-glyoxylate aminotransferase (SGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
    
 0.941
sga-2
Serine-glyoxylate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
    
 0.941
hprA
Hydroxypyruvate reductase, NAD(P)H-dependent; Plays a central role in assimilation of carbon. It converts hydroxypyruvate to glycerate as a key step in the serine cycle, and may also play an important role in C2 reactions, by interconverting glyoxylate and glycolate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
    
 0.940
ACS38288.1
Putative 2-hydroxyacid dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
 
  
 0.921
pccA
propionyl-CoA carboxylase alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.919
ACS41931.1
Putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the HpcH/HpaI aldolase family.
  
  
 
0.915
pccB
propionyl-CoA carboxylase beta chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.913
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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