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ACS39580.1 ACS39580.1 ACS39608.1 ACS39608.1 mtdB mtdB mptG mptG ACS39615.1 ACS39615.1 ACS39616.1 ACS39616.1 fhcB fhcB ACS39611.1 ACS39611.1 fae-2 fae-2 ACS39618.1 ACS39618.1 mch mch
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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ACS39580.1Putative transcriptional coactivator/pterin dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (125 aa)    
Predicted Functional Partners:
ACS39608.1
Orf7. Involved in tetrahydromethanopterin-linked formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative factor.
 
     0.774
mtdB
NAD(P)-dependent methylene tetrahydromethanopterin dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT.
 
     0.771
mptG
Ribofuranosylaminobenzene 5'-phosphate (RFAP) synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
     0.769
ACS39615.1
Orf19. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme.
 
     0.759
ACS39616.1
Orf20. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme.
 
     0.754
fhcB
Formyltransferase/hydrolase complex Fhc subunit B; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR).
 
     0.726
ACS39611.1
Orf9, involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme.
 
     0.721
fae-2
Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium.
 
     0.718
ACS39618.1
Orf22. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme.
 
     0.716
mch
N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase (methenyl-H4MPT cyclohydrolase); Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT.
 
     0.711
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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