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mptG mptG fae-2 fae-2 mtdB mtdB mch mch ACS39605.1 ACS39605.1 ACS39608.1 ACS39608.1 ACS39607.1 ACS39607.1 fae fae fae-3 fae-3 fhcC fhcC fhcD fhcD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
mptGRibofuranosylaminobenzene 5'-phosphate (RFAP) synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (332 aa)    
Predicted Functional Partners:
fae-2
Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium.
 
   
 0.902
mtdB
NAD(P)-dependent methylene tetrahydromethanopterin dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT.
 
     0.897
mch
N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase (methenyl-H4MPT cyclohydrolase); Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT.
 
   
 0.891
ACS39605.1
Tetrahydromethanopterin C1 transfer protein; Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme.
 
     0.867
ACS39608.1
Orf7. Involved in tetrahydromethanopterin-linked formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative factor.
 
     0.842
ACS39607.1
Orf5. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme; Belongs to the RimK family.
 
     0.833
fae
Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme.
 
   
 0.831
fae-3
Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme.
 
   
 0.830
fhcC
Formyltransferase/hydrolase complex Fhc subunit C; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR).
 
     0.802
fhcD
Formyltransferase/hydrolase complex Fhc subunit D; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the intermediate formylmethanofuran (formyl-MFR). Catalyzes the transfer of a formyl group from 5-formyl-H(4)MPT to MFR so as to produce tetrahydromethanopterin (H(4)MPT) and formyl-MFR, which is then hydrolyzed to formate and MFR; Belongs to the FTR family.
 
     0.802
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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