node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS39605.1 | fae | MexAM1_META1p1762 | MexAM1_META1p1339 | Tetrahydromethanopterin C1 transfer protein; Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | 0.794 |
ACS39605.1 | fae-2 | MexAM1_META1p1762 | MexAM1_META1p1766 | Tetrahydromethanopterin C1 transfer protein; Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | 0.848 |
ACS39605.1 | fae-3 | MexAM1_META1p1762 | MexAM1_META1p3356 | Tetrahydromethanopterin C1 transfer protein; Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | 0.793 |
ACS39605.1 | fhcA | MexAM1_META1p1762 | MexAM1_META1p1757 | Tetrahydromethanopterin C1 transfer protein; Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Formyltransferase/hydrolase complex Fhc subunit A; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR). May be catalyze the hydrolysis of formylmethanofuran (formyl-MFR) to yield formate and MFR. Belongs to the metallo-dependent hydrolases superfamily. FwdA/FmdA family. | 0.802 |
ACS39605.1 | fhcD | MexAM1_META1p1762 | MexAM1_META1p1756 | Tetrahydromethanopterin C1 transfer protein; Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Formyltransferase/hydrolase complex Fhc subunit D; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the intermediate formylmethanofuran (formyl-MFR). Catalyzes the transfer of a formyl group from 5-formyl-H(4)MPT to MFR so as to produce tetrahydromethanopterin (H(4)MPT) and formyl-MFR, which is then hydrolyzed to formate and MFR; Belongs to the FTR family. | 0.802 |
ACS39605.1 | mch | MexAM1_META1p1762 | MexAM1_META1p1763 | Tetrahydromethanopterin C1 transfer protein; Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase (methenyl-H4MPT cyclohydrolase); Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT. | 0.960 |
ACS39605.1 | mptG | MexAM1_META1p1762 | MexAM1_META1p1760 | Tetrahydromethanopterin C1 transfer protein; Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Ribofuranosylaminobenzene 5'-phosphate (RFAP) synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.867 |
ACS39605.1 | mtdA | MexAM1_META1p1762 | MexAM1_META1p1728 | Tetrahydromethanopterin C1 transfer protein; Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | NADP-dependent methylene-tetrahydromethanopterin/methylene- tetrahydrofolate dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT. Can also catalyze the reversible dehydrogenation of methylene-H(4)F with 20-fold lower catalytic efficiency. | 0.792 |
ACS39605.1 | mtdB | MexAM1_META1p1762 | MexAM1_META1p1761 | Tetrahydromethanopterin C1 transfer protein; Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | NAD(P)-dependent methylene tetrahydromethanopterin dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT. | 0.899 |
fae | ACS39605.1 | MexAM1_META1p1339 | MexAM1_META1p1762 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Tetrahydromethanopterin C1 transfer protein; Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | 0.794 |
fae | fae-2 | MexAM1_META1p1339 | MexAM1_META1p1766 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | 0.922 |
fae | fae-3 | MexAM1_META1p1339 | MexAM1_META1p3356 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | 0.915 |
fae | fhcA | MexAM1_META1p1339 | MexAM1_META1p1757 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Formyltransferase/hydrolase complex Fhc subunit A; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR). May be catalyze the hydrolysis of formylmethanofuran (formyl-MFR) to yield formate and MFR. Belongs to the metallo-dependent hydrolases superfamily. FwdA/FmdA family. | 0.789 |
fae | fhcD | MexAM1_META1p1339 | MexAM1_META1p1756 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Formyltransferase/hydrolase complex Fhc subunit D; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the intermediate formylmethanofuran (formyl-MFR). Catalyzes the transfer of a formyl group from 5-formyl-H(4)MPT to MFR so as to produce tetrahydromethanopterin (H(4)MPT) and formyl-MFR, which is then hydrolyzed to formate and MFR; Belongs to the FTR family. | 0.978 |
fae | glyA | MexAM1_META1p1339 | MexAM1_META1p3384 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.919 |
fae | mch | MexAM1_META1p1339 | MexAM1_META1p1763 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase (methenyl-H4MPT cyclohydrolase); Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT. | 0.942 |
fae | mptG | MexAM1_META1p1339 | MexAM1_META1p1760 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Ribofuranosylaminobenzene 5'-phosphate (RFAP) synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.831 |
fae | mtdA | MexAM1_META1p1339 | MexAM1_META1p1728 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | NADP-dependent methylene-tetrahydromethanopterin/methylene- tetrahydrofolate dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT. Can also catalyze the reversible dehydrogenation of methylene-H(4)F with 20-fold lower catalytic efficiency. | 0.990 |
fae | mtdB | MexAM1_META1p1339 | MexAM1_META1p1761 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | NAD(P)-dependent methylene tetrahydromethanopterin dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT. | 0.992 |
fae-2 | ACS39605.1 | MexAM1_META1p1766 | MexAM1_META1p1762 | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | Tetrahydromethanopterin C1 transfer protein; Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | 0.848 |