node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS41185.1 | dnaN | MexAM1_META1p3448 | MexAM1_META1p0002 | Putative ATP-dependent DNA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.957 |
ACS41185.1 | polA | MexAM1_META1p3448 | MexAM1_META1p2436 | Putative ATP-dependent DNA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.932 |
ACS41185.1 | xthA | MexAM1_META1p3448 | MexAM1_META1p1930 | Putative ATP-dependent DNA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI); Function of strongly homologous gene; enzyme. | 0.649 |
ACS41185.1 | xthA-2 | MexAM1_META1p3448 | MexAM1_META1p4420 | Putative ATP-dependent DNA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI); Function of strongly homologous gene; enzyme. | 0.649 |
ACS41567.1 | nth | MexAM1_META1p3881 | MexAM1_META1p0411 | Putative Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Endonuclease III DNA glycosylase/apyrimidinic (AP) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.918 |
ACS41567.1 | polA | MexAM1_META1p3881 | MexAM1_META1p2436 | Putative Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.599 |
ACS41567.1 | xthA | MexAM1_META1p3881 | MexAM1_META1p1930 | Putative Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI); Function of strongly homologous gene; enzyme. | 0.845 |
ACS41567.1 | xthA-2 | MexAM1_META1p3881 | MexAM1_META1p4420 | Putative Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI); Function of strongly homologous gene; enzyme. | 0.626 |
ACS41871.1 | xthA | MexAM1_META1p4234 | MexAM1_META1p1930 | Conserved hypothetical protein with putative pseudouridine synthase-like domain; Homologs of previously reported genes of unknown function; Belongs to the pseudouridine synthase RsuA family. | Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI); Function of strongly homologous gene; enzyme. | 0.783 |
ACS41871.1 | xthA-2 | MexAM1_META1p4234 | MexAM1_META1p4420 | Conserved hypothetical protein with putative pseudouridine synthase-like domain; Homologs of previously reported genes of unknown function; Belongs to the pseudouridine synthase RsuA family. | Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI); Function of strongly homologous gene; enzyme. | 0.783 |
dnaN | ACS41185.1 | MexAM1_META1p0002 | MexAM1_META1p3448 | DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Putative ATP-dependent DNA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.957 |
dnaN | mutY | MexAM1_META1p0002 | MexAM1_META1p3392 | DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.601 |
dnaN | polA | MexAM1_META1p0002 | MexAM1_META1p2436 | DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.988 |
dnaN | xthA | MexAM1_META1p0002 | MexAM1_META1p1930 | DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI); Function of strongly homologous gene; enzyme. | 0.740 |
dnaN | xthA-2 | MexAM1_META1p0002 | MexAM1_META1p4420 | DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI); Function of strongly homologous gene; enzyme. | 0.740 |
hfq | polA | MexAM1_META1p3025 | MexAM1_META1p2436 | Protein hfq, RNA-binding host factor; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.468 |
hfq | xthA | MexAM1_META1p3025 | MexAM1_META1p1930 | Protein hfq, RNA-binding host factor; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI); Function of strongly homologous gene; enzyme. | 0.732 |
hfq | xthA-2 | MexAM1_META1p3025 | MexAM1_META1p4420 | Protein hfq, RNA-binding host factor; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI); Function of strongly homologous gene; enzyme. | 0.732 |
mutY | dnaN | MexAM1_META1p3392 | MexAM1_META1p0002 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.601 |
mutY | polA | MexAM1_META1p3392 | MexAM1_META1p2436 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.506 |