node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS39791.1 | ACS40629.1 | MexAM1_META1p1981 | MexAM1_META1p2876 | Putative cob(II)yrinic acid a,c-diamide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.812 |
ACS39791.1 | cobB | MexAM1_META1p1981 | MexAM1_META1p0805 | Putative cob(II)yrinic acid a,c-diamide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.850 |
ACS39791.1 | cobC | MexAM1_META1p1981 | MexAM1_META1p5176 | Putative cob(II)yrinic acid a,c-diamide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Threonine-phosphate decarboxylase (L-threonine-O-3- phosphate decarboxylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.723 |
ACS39791.1 | cobH | MexAM1_META1p1981 | MexAM1_META1p1326 | Putative cob(II)yrinic acid a,c-diamide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Precorrin-8X methylmutase (Precorrin isomerase) (HBA synthase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.656 |
ACS39791.1 | cobK | MexAM1_META1p1981 | MexAM1_META1p5173 | Putative cob(II)yrinic acid a,c-diamide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Precorrin-6A reductase (Precorrin-6X reductase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.650 |
ACS39791.1 | cobL | MexAM1_META1p1981 | MexAM1_META1p0799 | Putative cob(II)yrinic acid a,c-diamide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Precorrin-6Y C5,15-methyltransferase (decarboxylating); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.716 |
ACS39791.1 | cobP | MexAM1_META1p1981 | MexAM1_META1p1336 | Putative cob(II)yrinic acid a,c-diamide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Bifunctional adenosylcobalamin biosynthesis protein cobP; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.911 |
ACS39791.1 | cobQ | MexAM1_META1p1981 | MexAM1_META1p5174 | Putative cob(II)yrinic acid a,c-diamide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.783 |
ACS39791.1 | cobT | MexAM1_META1p1981 | MexAM1_META1p0682 | Putative cob(II)yrinic acid a,c-diamide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.988 |
ACS39791.1 | ssuE | MexAM1_META1p1981 | MexAM1_META1p3632 | Putative cob(II)yrinic acid a,c-diamide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | NAD(P)H-dependent FMN reductase; Function of strongly homologous gene; enzyme. | 0.905 |
ACS40629.1 | ACS39791.1 | MexAM1_META1p2876 | MexAM1_META1p1981 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Putative cob(II)yrinic acid a,c-diamide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.812 |
cobB | ACS39791.1 | MexAM1_META1p0805 | MexAM1_META1p1981 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Putative cob(II)yrinic acid a,c-diamide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.850 |
cobB | cobC | MexAM1_META1p0805 | MexAM1_META1p5176 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Threonine-phosphate decarboxylase (L-threonine-O-3- phosphate decarboxylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.711 |
cobB | cobH | MexAM1_META1p0805 | MexAM1_META1p1326 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-8X methylmutase (Precorrin isomerase) (HBA synthase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.994 |
cobB | cobK | MexAM1_META1p0805 | MexAM1_META1p5173 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-6A reductase (Precorrin-6X reductase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.851 |
cobB | cobL | MexAM1_META1p0805 | MexAM1_META1p0799 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-6Y C5,15-methyltransferase (decarboxylating); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.903 |
cobB | cobP | MexAM1_META1p0805 | MexAM1_META1p1336 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Bifunctional adenosylcobalamin biosynthesis protein cobP; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.934 |
cobB | cobQ | MexAM1_META1p0805 | MexAM1_META1p5174 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.987 |
cobB | cobT | MexAM1_META1p0805 | MexAM1_META1p0682 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.975 |
cobC | ACS39791.1 | MexAM1_META1p5176 | MexAM1_META1p1981 | Threonine-phosphate decarboxylase (L-threonine-O-3- phosphate decarboxylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Putative cob(II)yrinic acid a,c-diamide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.723 |