STRINGSTRING
ACS39840.1 ACS39840.1 ihfA ihfA rpsG rpsG rplU rplU ACS42480.1 ACS42480.1 rpoB rpoB ACS39682.1 ACS39682.1 dnaJ dnaJ ACS41179.1 ACS41179.1 ACS42318.1 ACS42318.1 ACS42858.1 ACS42858.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACS39840.1Putative transcriptional regulator, MerR family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (165 aa)    
Predicted Functional Partners:
ihfA
Integration host factor (IHF), DNA-binding protein, alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family.
 
  
 0.942
rpsG
30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.
   
    0.813
rplU
50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
   
    0.804
ACS42480.1
Putative PAS sensor hybrid histidine kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative receptor.
   
 
 0.729
rpoB
RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.640
ACS39682.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
 
 0.542
dnaJ
Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...]
  
 
 0.542
ACS41179.1
Putative chaperone protein, DnaJ domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor.
  
 
 0.542
ACS42318.1
Chaperone DnaJ domain protein, putative heat shock protein; Function of strongly homologous gene; factor.
  
 
 0.542
ACS42858.1
Conserved hypothetical protein, containing N-terminal fragment of heat shock protein DnaJ; Homologs of previously reported genes of unknown function.
  
 
 0.542
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
Server load: low (14%) [HD]