node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS39923.1 | ACS39925.1 | MexAM1_META1p2128 | MexAM1_META1p2130 | Fumarylacetoacetate (FAA) hydrolase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Putative acyl-coenzyme A synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.533 |
ACS39923.1 | oxlT-5 | MexAM1_META1p2128 | MexAM1_META1p2127 | Fumarylacetoacetate (FAA) hydrolase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Putative oxalate/formate antiporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | 0.773 |
ACS39923.1 | panE | MexAM1_META1p2128 | MexAM1_META1p2129 | Fumarylacetoacetate (FAA) hydrolase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 2-dehydropantoate 2-reductase (ketopantoate reductase); Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.780 |
ACS39925.1 | ACS39923.1 | MexAM1_META1p2130 | MexAM1_META1p2128 | Putative acyl-coenzyme A synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Fumarylacetoacetate (FAA) hydrolase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.533 |
ACS39925.1 | oxlT-5 | MexAM1_META1p2130 | MexAM1_META1p2127 | Putative acyl-coenzyme A synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Putative oxalate/formate antiporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | 0.525 |
ACS39925.1 | panE | MexAM1_META1p2130 | MexAM1_META1p2129 | Putative acyl-coenzyme A synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 2-dehydropantoate 2-reductase (ketopantoate reductase); Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.907 |
ACS40889.1 | panB | MexAM1_META1p3141 | MexAM1_META1p1701 | Conserved hypothetical protein, putative domain: Ketopantoate reductase ApbA/PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 3-methyl-2-oxobutanoate hydroxymethyltransferase, pantothenate biosynthetic process; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.928 |
ACS40889.1 | panC | MexAM1_META1p3141 | MexAM1_META1p2235 | Conserved hypothetical protein, putative domain: Ketopantoate reductase ApbA/PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.928 |
ACS40889.1 | panE | MexAM1_META1p3141 | MexAM1_META1p2129 | Conserved hypothetical protein, putative domain: Ketopantoate reductase ApbA/PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 2-dehydropantoate 2-reductase (ketopantoate reductase); Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.926 |
ACS40889.1 | ribAB | MexAM1_META1p3141 | MexAM1_META1p3198 | Conserved hypothetical protein, putative domain: Ketopantoate reductase ApbA/PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.451 |
oxlT-5 | ACS39923.1 | MexAM1_META1p2127 | MexAM1_META1p2128 | Putative oxalate/formate antiporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | Fumarylacetoacetate (FAA) hydrolase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.773 |
oxlT-5 | ACS39925.1 | MexAM1_META1p2127 | MexAM1_META1p2130 | Putative oxalate/formate antiporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | Putative acyl-coenzyme A synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.525 |
oxlT-5 | panE | MexAM1_META1p2127 | MexAM1_META1p2129 | Putative oxalate/formate antiporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | 2-dehydropantoate 2-reductase (ketopantoate reductase); Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.596 |
panB | ACS40889.1 | MexAM1_META1p1701 | MexAM1_META1p3141 | 3-methyl-2-oxobutanoate hydroxymethyltransferase, pantothenate biosynthetic process; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | Conserved hypothetical protein, putative domain: Ketopantoate reductase ApbA/PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.928 |
panB | panC | MexAM1_META1p1701 | MexAM1_META1p2235 | 3-methyl-2-oxobutanoate hydroxymethyltransferase, pantothenate biosynthetic process; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.998 |
panB | panE | MexAM1_META1p1701 | MexAM1_META1p2129 | 3-methyl-2-oxobutanoate hydroxymethyltransferase, pantothenate biosynthetic process; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 2-dehydropantoate 2-reductase (ketopantoate reductase); Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.928 |
panB | ribAB | MexAM1_META1p1701 | MexAM1_META1p3198 | 3-methyl-2-oxobutanoate hydroxymethyltransferase, pantothenate biosynthetic process; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.539 |
panC | ACS40889.1 | MexAM1_META1p2235 | MexAM1_META1p3141 | Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | Conserved hypothetical protein, putative domain: Ketopantoate reductase ApbA/PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.928 |
panC | panB | MexAM1_META1p2235 | MexAM1_META1p1701 | Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase, pantothenate biosynthetic process; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.998 |
panC | panE | MexAM1_META1p2235 | MexAM1_META1p2129 | Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 2-dehydropantoate 2-reductase (ketopantoate reductase); Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.928 |