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ibd2 ibd2 meaC meaC etfA etfA ecm ecm ACS41189.1 ACS41189.1 hbdA hbdA croR croR ACS41558.1 ACS41558.1 ACS42261.1 ACS42261.1 etfB etfB ccr ccr
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ibd2isobutyryl-CoA dehydrogenase; Function experimentally demonstrated in the studied strain; enzyme. (562 aa)    
Predicted Functional Partners:
meaC
Mesaconyl-CoA hydratase; Part of the glyoxylate regeneration cycle that is essential for growth on C1 and C2 compounds; Function experimentally demonstrated in the studied strain; enzyme.
 
 0.983
etfA
Electron transfer flavoprotein alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.971
ecm
ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate.
 
 
 0.965
ACS41189.1
3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 0.917
hbdA
3-hydroxybutyryl-CoA dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.875
croR
Crotonase; Involved in the regeneration of glyoxylate from a molecule of acetyl-CoA.
 
 0.853
ACS41558.1
Enoyl-CoA hydratase/isomerase family protein; Function of strongly homologous gene; enzyme.
 
 0.831
ACS42261.1
Putative enoyl-CoA hydratase/isomerase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
 0.830
etfB
Electron transfer flavoprotein beta subunit; Function of strongly homologous gene; enzyme.
 
 
 0.823
ccr
crotonyl-CoA carboxylase/reductase; Function experimentally demonstrated in the studied strain; enzyme.
  
 
 0.812
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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