node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS40808.1 | ACS41849.1 | MexAM1_META1p3060 | MexAM1_META1p4211 | Putative cystathionine gamma-synthase, PLP-dependent (metB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.907 |
ACS40808.1 | ACS42546.1 | MexAM1_META1p3060 | MexAM1_META1p4939 | Putative cystathionine gamma-synthase, PLP-dependent (metB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Putative sulfite reductase (NADPH); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.923 |
ACS40808.1 | cysG | MexAM1_META1p3060 | MexAM1_META1p3434 | Putative cystathionine gamma-synthase, PLP-dependent (metB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.509 |
ACS40808.1 | cysH | MexAM1_META1p3060 | MexAM1_META1p2230 | Putative cystathionine gamma-synthase, PLP-dependent (metB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | 0.402 |
ACS40808.1 | cysI | MexAM1_META1p3060 | MexAM1_META1p2233 | Putative cystathionine gamma-synthase, PLP-dependent (metB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Sulfite reductase, beta subunit, NADPH-dependent hemoprotein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.925 |
ACS40808.1 | cysJ | MexAM1_META1p3060 | MexAM1_META1p2232 | Putative cystathionine gamma-synthase, PLP-dependent (metB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Sulfite reductase, alpha subunit (flavoprotein); Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | 0.919 |
ACS40808.1 | cysK | MexAM1_META1p3060 | MexAM1_META1p0751 | Putative cystathionine gamma-synthase, PLP-dependent (metB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Subunit of cysteine synthase A and O-acetylserine sulfhydrolase A, PLP-dependent enzyme; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.984 |
ACS40808.1 | cysK-2 | MexAM1_META1p3060 | MexAM1_META1p1278 | Putative cystathionine gamma-synthase, PLP-dependent (metB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.987 |
ACS40808.1 | sseA | MexAM1_META1p3060 | MexAM1_META1p2537 | Putative cystathionine gamma-synthase, PLP-dependent (metB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 3-mercaptopyruvate sulfurtransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.860 |
ACS41849.1 | ACS40808.1 | MexAM1_META1p4211 | MexAM1_META1p3060 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Putative cystathionine gamma-synthase, PLP-dependent (metB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.907 |
ACS41849.1 | ACS42546.1 | MexAM1_META1p4211 | MexAM1_META1p4939 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Putative sulfite reductase (NADPH); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.920 |
ACS41849.1 | cysI | MexAM1_META1p4211 | MexAM1_META1p2233 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Sulfite reductase, beta subunit, NADPH-dependent hemoprotein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.909 |
ACS41849.1 | cysJ | MexAM1_META1p4211 | MexAM1_META1p2232 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Sulfite reductase, alpha subunit (flavoprotein); Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | 0.913 |
ACS41849.1 | cysK | MexAM1_META1p4211 | MexAM1_META1p0751 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Subunit of cysteine synthase A and O-acetylserine sulfhydrolase A, PLP-dependent enzyme; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.916 |
ACS41849.1 | cysK-2 | MexAM1_META1p4211 | MexAM1_META1p1278 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.916 |
ACS42546.1 | ACS40808.1 | MexAM1_META1p4939 | MexAM1_META1p3060 | Putative sulfite reductase (NADPH); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative cystathionine gamma-synthase, PLP-dependent (metB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.923 |
ACS42546.1 | ACS41849.1 | MexAM1_META1p4939 | MexAM1_META1p4211 | Putative sulfite reductase (NADPH); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.920 |
ACS42546.1 | cysG | MexAM1_META1p4939 | MexAM1_META1p3434 | Putative sulfite reductase (NADPH); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.910 |
ACS42546.1 | cysH | MexAM1_META1p4939 | MexAM1_META1p2230 | Putative sulfite reductase (NADPH); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | 0.979 |
ACS42546.1 | cysI | MexAM1_META1p4939 | MexAM1_META1p2233 | Putative sulfite reductase (NADPH); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Sulfite reductase, beta subunit, NADPH-dependent hemoprotein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.997 |