node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS40889.1 | panB | MexAM1_META1p3141 | MexAM1_META1p1701 | Conserved hypothetical protein, putative domain: Ketopantoate reductase ApbA/PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 3-methyl-2-oxobutanoate hydroxymethyltransferase, pantothenate biosynthetic process; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.928 |
ACS40889.1 | panC | MexAM1_META1p3141 | MexAM1_META1p2235 | Conserved hypothetical protein, putative domain: Ketopantoate reductase ApbA/PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.928 |
ACS40889.1 | panE | MexAM1_META1p3141 | MexAM1_META1p2129 | Conserved hypothetical protein, putative domain: Ketopantoate reductase ApbA/PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 2-dehydropantoate 2-reductase (ketopantoate reductase); Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.926 |
argJ | guaA | MexAM1_META1p0204 | MexAM1_META1p3135 | Glutamate N-acetyltransferase/amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.450 |
argJ | panB | MexAM1_META1p0204 | MexAM1_META1p1701 | Glutamate N-acetyltransferase/amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase, pantothenate biosynthetic process; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.683 |
argJ | panC | MexAM1_META1p0204 | MexAM1_META1p2235 | Glutamate N-acetyltransferase/amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.728 |
cmk | guaA | MexAM1_META1p2119 | MexAM1_META1p3135 | Cytidine monophosphate (CMP) kinase; Function of strongly homologous gene; enzyme. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.468 |
cmk | panC | MexAM1_META1p2119 | MexAM1_META1p2235 | Cytidine monophosphate (CMP) kinase; Function of strongly homologous gene; enzyme. | Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.910 |
coaA | coaBC | MexAM1_META1p2521 | MexAM1_META1p4307 | Pantothenate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Coenzyme A biosynthesis bifunctional protein coaBC (DNA/pantothenate metabolism flavoprotein); Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.924 |
coaA | panC | MexAM1_META1p2521 | MexAM1_META1p2235 | Pantothenate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.920 |
coaBC | coaA | MexAM1_META1p4307 | MexAM1_META1p2521 | Coenzyme A biosynthesis bifunctional protein coaBC (DNA/pantothenate metabolism flavoprotein); Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.924 |
coaBC | panB | MexAM1_META1p4307 | MexAM1_META1p1701 | Coenzyme A biosynthesis bifunctional protein coaBC (DNA/pantothenate metabolism flavoprotein); Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase, pantothenate biosynthetic process; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.512 |
coaBC | panC | MexAM1_META1p4307 | MexAM1_META1p2235 | Coenzyme A biosynthesis bifunctional protein coaBC (DNA/pantothenate metabolism flavoprotein); Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.904 |
dusA | guaA | MexAM1_META1p0720 | MexAM1_META1p3135 | tRNA-dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.441 |
dusA | panC | MexAM1_META1p0720 | MexAM1_META1p2235 | tRNA-dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.705 |
guaA | argJ | MexAM1_META1p3135 | MexAM1_META1p0204 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Glutamate N-acetyltransferase/amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | 0.450 |
guaA | cmk | MexAM1_META1p3135 | MexAM1_META1p2119 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Cytidine monophosphate (CMP) kinase; Function of strongly homologous gene; enzyme. | 0.468 |
guaA | dusA | MexAM1_META1p3135 | MexAM1_META1p0720 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | tRNA-dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | 0.441 |
guaA | panB | MexAM1_META1p3135 | MexAM1_META1p1701 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 3-methyl-2-oxobutanoate hydroxymethyltransferase, pantothenate biosynthetic process; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.793 |
guaA | panC | MexAM1_META1p3135 | MexAM1_META1p2235 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.826 |