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folE folE folK folK folP folP ptpS ptpS folB folB ftsH ftsH ribAB ribAB moaA moaA folC folC ACS39616.1 ACS39616.1 mazG mazG
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
folEGTP cyclohydrolase I; Function of strongly homologous gene; enzyme. (269 aa)    
Predicted Functional Partners:
folK
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the HPPK family.
  
 0.997
folP
7,8-dihydropteroate synthase (dihydropteroate synthase (DHPS), dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
 0.973
ptpS
Putative 6-pyruvol tetrahydrobiopterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
  
 
 0.970
folB
Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
  
 0.970
ftsH
Cell division protease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
 
  
 0.969
ribAB
3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
  
 
 0.946
moaA
Molybdenum biosynthetic protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
    
  0.910
folC
Bifunctional folylpolyglutamate synthase and dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family.
  
  
 0.895
ACS39616.1
Orf20. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme.
  
  
 0.863
mazG
Nucleoside triphosphate pyrophosphohydrolase MazG; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
    
 0.843
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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