node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS40068.1 | rppH | MexAM1_META1p2284 | MexAM1_META1p2285 | Hypothetical protein; No homology to any previously reported sequences. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.689 |
ACS40072.1 | rppH | MexAM1_META1p2288 | MexAM1_META1p2285 | Putative periplasmic carboxyl-terminal processing protease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the peptidase S41A family. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.792 |
ACS42206.1 | rppH | MexAM1_META1p4577 | MexAM1_META1p2285 | Putative metallo-dependent hydrolase, putative deoxyribonuclease, TatD family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.847 |
dapF | rppH | MexAM1_META1p2917 | MexAM1_META1p2285 | Diaminopimelate epimerase (DAP epimerase); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.840 |
hppa | pitA | MexAM1_META1p3299 | MexAM1_META1p5245 | H+ translocating pyrophosphate synthase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | Low-affinity phosphate transport protein (PiT family); Function of strongly homologous gene; transporter. | 0.508 |
hppa | ppk | MexAM1_META1p3299 | MexAM1_META1p2049 | H+ translocating pyrophosphate synthase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | Polyphosphate kinase, component of RNA degradosome; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.661 |
hppa | ppnK | MexAM1_META1p3299 | MexAM1_META1p0369 | H+ translocating pyrophosphate synthase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.449 |
hppa | rppH | MexAM1_META1p3299 | MexAM1_META1p2285 | H+ translocating pyrophosphate synthase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.662 |
nnrE | rppH | MexAM1_META1p2375 | MexAM1_META1p2285 | Putative carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of [...] | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.853 |
pitA | hppa | MexAM1_META1p5245 | MexAM1_META1p3299 | Low-affinity phosphate transport protein (PiT family); Function of strongly homologous gene; transporter. | H+ translocating pyrophosphate synthase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | 0.508 |
pitA | ppk | MexAM1_META1p5245 | MexAM1_META1p2049 | Low-affinity phosphate transport protein (PiT family); Function of strongly homologous gene; transporter. | Polyphosphate kinase, component of RNA degradosome; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.738 |
pitA | ppnK | MexAM1_META1p5245 | MexAM1_META1p0369 | Low-affinity phosphate transport protein (PiT family); Function of strongly homologous gene; transporter. | Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.523 |
pitA | rppH | MexAM1_META1p5245 | MexAM1_META1p2285 | Low-affinity phosphate transport protein (PiT family); Function of strongly homologous gene; transporter. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.625 |
ppk | hppa | MexAM1_META1p2049 | MexAM1_META1p3299 | Polyphosphate kinase, component of RNA degradosome; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | H+ translocating pyrophosphate synthase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | 0.661 |
ppk | pitA | MexAM1_META1p2049 | MexAM1_META1p5245 | Polyphosphate kinase, component of RNA degradosome; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | Low-affinity phosphate transport protein (PiT family); Function of strongly homologous gene; transporter. | 0.738 |
ppk | ppnK | MexAM1_META1p2049 | MexAM1_META1p0369 | Polyphosphate kinase, component of RNA degradosome; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.730 |
ppk | rppH | MexAM1_META1p2049 | MexAM1_META1p2285 | Polyphosphate kinase, component of RNA degradosome; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.703 |
ppnK | hppa | MexAM1_META1p0369 | MexAM1_META1p3299 | Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | H+ translocating pyrophosphate synthase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | 0.449 |
ppnK | pitA | MexAM1_META1p0369 | MexAM1_META1p5245 | Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Low-affinity phosphate transport protein (PiT family); Function of strongly homologous gene; transporter. | 0.523 |
ppnK | ppk | MexAM1_META1p0369 | MexAM1_META1p2049 | Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Polyphosphate kinase, component of RNA degradosome; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.730 |