node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ecm | epi | MexAM1_META1p0180 | MexAM1_META1p0839 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.995 |
ecm | mcmA | MexAM1_META1p0180 | MexAM1_META1p5251 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.978 |
ecm | mcmB | MexAM1_META1p0180 | MexAM1_META1p2390 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | methylmalonyl-CoA beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.982 |
ecm | mdh | MexAM1_META1p0180 | MexAM1_META1p1537 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.416 |
ecm | meaB | MexAM1_META1p0180 | MexAM1_META1p0188 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | methylmalonyl-CoA mutase accessory protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.997 |
ecm | pccB | MexAM1_META1p0180 | MexAM1_META1p0172 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | propionyl-CoA carboxylase beta chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.886 |
ecm | sucD | MexAM1_META1p0180 | MexAM1_META1p1539 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.423 |
epi | ecm | MexAM1_META1p0839 | MexAM1_META1p0180 | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | 0.995 |
epi | matB | MexAM1_META1p0839 | MexAM1_META1p0644 | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Malonyl CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.901 |
epi | mcmA | MexAM1_META1p0839 | MexAM1_META1p5251 | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.987 |
epi | mcmB | MexAM1_META1p0839 | MexAM1_META1p2390 | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | methylmalonyl-CoA beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.976 |
epi | meaB | MexAM1_META1p0839 | MexAM1_META1p0188 | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | methylmalonyl-CoA mutase accessory protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.935 |
epi | pccB | MexAM1_META1p0839 | MexAM1_META1p0172 | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | propionyl-CoA carboxylase beta chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.994 |
matB | epi | MexAM1_META1p0644 | MexAM1_META1p0839 | Malonyl CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.901 |
matB | mcmA | MexAM1_META1p0644 | MexAM1_META1p5251 | Malonyl CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.945 |
matB | mcmB | MexAM1_META1p0644 | MexAM1_META1p2390 | Malonyl CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | methylmalonyl-CoA beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.942 |
matB | meaB | MexAM1_META1p0644 | MexAM1_META1p0188 | Malonyl CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | methylmalonyl-CoA mutase accessory protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.673 |
mcmA | ecm | MexAM1_META1p5251 | MexAM1_META1p0180 | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | 0.978 |
mcmA | epi | MexAM1_META1p5251 | MexAM1_META1p0839 | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.987 |
mcmA | matB | MexAM1_META1p5251 | MexAM1_META1p0644 | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Malonyl CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.945 |