node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS40182.1 | ACS40184.1 | MexAM1_META1p2399 | MexAM1_META1p2401 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Peptidase, M50 family protein; Function of strongly homologous gene; enzyme. | 0.944 |
ACS40182.1 | ACS40185.1 | MexAM1_META1p2399 | MexAM1_META1p2402 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | TonB-dependent siderophore receptor; Function of strongly homologous gene; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.943 |
ACS40182.1 | secA-2 | MexAM1_META1p2399 | MexAM1_META1p2400 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Putative preprotein translocase subunit, ATPase (secA-like); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.764 |
ACS40184.1 | ACS40182.1 | MexAM1_META1p2401 | MexAM1_META1p2399 | Peptidase, M50 family protein; Function of strongly homologous gene; enzyme. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.944 |
ACS40184.1 | ACS40185.1 | MexAM1_META1p2401 | MexAM1_META1p2402 | Peptidase, M50 family protein; Function of strongly homologous gene; enzyme. | TonB-dependent siderophore receptor; Function of strongly homologous gene; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.950 |
ACS40184.1 | secA-2 | MexAM1_META1p2401 | MexAM1_META1p2400 | Peptidase, M50 family protein; Function of strongly homologous gene; enzyme. | Putative preprotein translocase subunit, ATPase (secA-like); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.858 |
ACS40185.1 | ACS40182.1 | MexAM1_META1p2402 | MexAM1_META1p2399 | TonB-dependent siderophore receptor; Function of strongly homologous gene; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.943 |
ACS40185.1 | ACS40184.1 | MexAM1_META1p2402 | MexAM1_META1p2401 | TonB-dependent siderophore receptor; Function of strongly homologous gene; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Peptidase, M50 family protein; Function of strongly homologous gene; enzyme. | 0.950 |
ACS40185.1 | secA-2 | MexAM1_META1p2402 | MexAM1_META1p2400 | TonB-dependent siderophore receptor; Function of strongly homologous gene; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Putative preprotein translocase subunit, ATPase (secA-like); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.944 |
ACS40185.1 | secB | MexAM1_META1p2402 | MexAM1_META1p1450 | TonB-dependent siderophore receptor; Function of strongly homologous gene; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Protein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. | 0.403 |
ACS40185.1 | secY | MexAM1_META1p2402 | MexAM1_META1p2172 | TonB-dependent siderophore receptor; Function of strongly homologous gene; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Protein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.403 |
engA | rplT | MexAM1_META1p4433 | MexAM1_META1p1522 | GTP-binding protein EngA, GTPase; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | 0.555 |
engA | secA | MexAM1_META1p4433 | MexAM1_META1p1371 | GTP-binding protein EngA, GTPase; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Preprotein translocase subunit, ATPase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. | 0.813 |
engA | secA-2 | MexAM1_META1p4433 | MexAM1_META1p2400 | GTP-binding protein EngA, GTPase; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Putative preprotein translocase subunit, ATPase (secA-like); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.830 |
polA | secA | MexAM1_META1p2436 | MexAM1_META1p1371 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Preprotein translocase subunit, ATPase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. | 0.873 |
polA | secA-2 | MexAM1_META1p2436 | MexAM1_META1p2400 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Putative preprotein translocase subunit, ATPase (secA-like); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.889 |
polA | secG | MexAM1_META1p2436 | MexAM1_META1p5111 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Putative secG: preprotein translocase; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.490 |
polA | secY | MexAM1_META1p2436 | MexAM1_META1p2172 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Protein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.510 |
rplT | engA | MexAM1_META1p1522 | MexAM1_META1p4433 | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | GTP-binding protein EngA, GTPase; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.555 |
rplT | secA | MexAM1_META1p1522 | MexAM1_META1p1371 | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | Preprotein translocase subunit, ATPase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. | 0.754 |