node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS42704.1 | ychF | MexAM1_META1p5100 | MexAM1_META1p2438 | Putative L-allo-threonine aldolase (ltaE-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative GTP-binding protein with nucleoside triP hydrolase domain; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. | 0.845 |
argS | guaA | MexAM1_META1p3624 | MexAM1_META1p3135 | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.913 |
argS | lepA | MexAM1_META1p3624 | MexAM1_META1p1025 | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | GTP-binding protein lepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.817 |
argS | pheT | MexAM1_META1p3624 | MexAM1_META1p1524 | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | Phenylalanine tRNA synthetase, beta-subunit; Function of strongly homologous gene; enzyme; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.897 |
argS | prfA | MexAM1_META1p3624 | MexAM1_META1p0729 | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | Peptide chain release factor RF-1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.802 |
argS | prs | MexAM1_META1p3624 | MexAM1_META1p4249 | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.848 |
argS | rpsG | MexAM1_META1p3624 | MexAM1_META1p2149 | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | 30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. | 0.853 |
argS | ychF | MexAM1_META1p3624 | MexAM1_META1p2438 | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | Putative GTP-binding protein with nucleoside triP hydrolase domain; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. | 0.842 |
guaA | argS | MexAM1_META1p3135 | MexAM1_META1p3624 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | 0.913 |
guaA | lepA | MexAM1_META1p3135 | MexAM1_META1p1025 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | GTP-binding protein lepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.528 |
guaA | pheT | MexAM1_META1p3135 | MexAM1_META1p1524 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Phenylalanine tRNA synthetase, beta-subunit; Function of strongly homologous gene; enzyme; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.923 |
guaA | prs | MexAM1_META1p3135 | MexAM1_META1p4249 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.828 |
guaA | pth | MexAM1_META1p3135 | MexAM1_META1p2439 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Peptidyl-tRNA hydrolase (PTH); The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. | 0.590 |
guaA | rpsG | MexAM1_META1p3135 | MexAM1_META1p2149 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. | 0.809 |
guaA | ychF | MexAM1_META1p3135 | MexAM1_META1p2438 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Putative GTP-binding protein with nucleoside triP hydrolase domain; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. | 0.850 |
lepA | argS | MexAM1_META1p1025 | MexAM1_META1p3624 | GTP-binding protein lepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. | 0.817 |
lepA | guaA | MexAM1_META1p1025 | MexAM1_META1p3135 | GTP-binding protein lepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.528 |
lepA | pheT | MexAM1_META1p1025 | MexAM1_META1p1524 | GTP-binding protein lepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Phenylalanine tRNA synthetase, beta-subunit; Function of strongly homologous gene; enzyme; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.547 |
lepA | prfA | MexAM1_META1p1025 | MexAM1_META1p0729 | GTP-binding protein lepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Peptide chain release factor RF-1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.908 |
lepA | pth | MexAM1_META1p1025 | MexAM1_META1p2439 | GTP-binding protein lepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Peptidyl-tRNA hydrolase (PTH); The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. | 0.573 |