node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS38751.1 | ACS40286.1 | MexAM1_META1p0830 | MexAM1_META1p2507 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative Methionyl-tRNA formyltransferase (partial); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.909 |
ACS38751.1 | dfrA | MexAM1_META1p0830 | MexAM1_META1p2852 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.963 |
ACS38751.1 | fch | MexAM1_META1p0830 | MexAM1_META1p1729 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Methenyl tetrahydrofolate cyclohydrolase; Required for both C1 and C2 metabolism; Belongs to the cyclodeaminase/cyclohydrolase family. | 0.910 |
ACS38751.1 | fmt | MexAM1_META1p0830 | MexAM1_META1p1529 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.970 |
ACS38751.1 | gcvT | MexAM1_META1p0830 | MexAM1_META1p0622 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Function of strongly homologous gene; enzyme. | 0.962 |
ACS38751.1 | glyA | MexAM1_META1p0830 | MexAM1_META1p3384 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.948 |
ACS38751.1 | metG | MexAM1_META1p0830 | MexAM1_META1p4578 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. | 0.918 |
ACS38751.1 | metH | MexAM1_META1p0830 | MexAM1_META1p1494 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.924 |
ACS38751.1 | nusB | MexAM1_META1p0830 | MexAM1_META1p3374 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Transcription antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.834 |
ACS38751.1 | purN | MexAM1_META1p0830 | MexAM1_META1p2044 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.967 |
ACS40286.1 | ACS38751.1 | MexAM1_META1p2507 | MexAM1_META1p0830 | Putative Methionyl-tRNA formyltransferase (partial); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.909 |
ACS40286.1 | dfrA | MexAM1_META1p2507 | MexAM1_META1p2852 | Putative Methionyl-tRNA formyltransferase (partial); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.922 |
ACS40286.1 | fch | MexAM1_META1p2507 | MexAM1_META1p1729 | Putative Methionyl-tRNA formyltransferase (partial); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Methenyl tetrahydrofolate cyclohydrolase; Required for both C1 and C2 metabolism; Belongs to the cyclodeaminase/cyclohydrolase family. | 0.910 |
ACS40286.1 | fmt | MexAM1_META1p2507 | MexAM1_META1p1529 | Putative Methionyl-tRNA formyltransferase (partial); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.914 |
ACS40286.1 | gcvT | MexAM1_META1p2507 | MexAM1_META1p0622 | Putative Methionyl-tRNA formyltransferase (partial); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Function of strongly homologous gene; enzyme. | 0.920 |
ACS40286.1 | glyA | MexAM1_META1p2507 | MexAM1_META1p3384 | Putative Methionyl-tRNA formyltransferase (partial); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.920 |
ACS40286.1 | metG | MexAM1_META1p2507 | MexAM1_META1p4578 | Putative Methionyl-tRNA formyltransferase (partial); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. | 0.918 |
ACS40286.1 | metH | MexAM1_META1p2507 | MexAM1_META1p1494 | Putative Methionyl-tRNA formyltransferase (partial); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.924 |
ACS40286.1 | nusB | MexAM1_META1p2507 | MexAM1_META1p3374 | Putative Methionyl-tRNA formyltransferase (partial); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Transcription antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.834 |
ACS40286.1 | purN | MexAM1_META1p2507 | MexAM1_META1p2044 | Putative Methionyl-tRNA formyltransferase (partial); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.925 |