STRINGSTRING
hisH hisH hisB hisB hisA hisA hisF hisF hisE hisE hisD hisD hisI hisI hisG hisG hisC hisC ACS39610.1 ACS39610.1 cobC cobC
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisHGlutamine amidotransferase, subunit with HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (220 aa)    
Predicted Functional Partners:
hisB
Imidazoleglycerol-phosphate dehydratase; Function of strongly homologous gene; enzyme.
 
 0.999
hisA
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of strongly homologous gene; enzyme.
 
 0.999
hisF
Imidazole glycerol phosphate synthase, subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 0.999
hisE
phosphoribosyl-ATP pyrophosphatase; Function of strongly homologous gene; enzyme.
 
  
 0.982
hisD
Bifunctional HisD: L-histidinal:NAD+ dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.977
hisI
Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.977
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.974
hisC
Histidinol-phosphate aminotransferase; Function of strongly homologous gene; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.950
ACS39610.1
Tetrahydromethanopterin-linked formaldehyde oxidation protein; Function experimentally demonstrated in the studied strain; putative enzyme; Belongs to the HisA/HisF family.
  
  
  0.919
cobC
Threonine-phosphate decarboxylase (L-threonine-O-3- phosphate decarboxylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.898
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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