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ilvE ilvE leuA leuA ilvD-2 ilvD-2 ilvD ilvD ACS41918.1 ACS41918.1 ACS42657.1 ACS42657.1 panB panB ACS40808.1 ACS40808.1 ilvA ilvA gshA gshA hom hom
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ilvEPutative branched-chain amino acid transferase (ilvE-like); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (293 aa)    
Predicted Functional Partners:
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 0.998
ilvD-2
Putative dihydroxyacid dehydratase (ilvD-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the IlvD/Edd family.
  
 0.977
ilvD
Dihydroxyacid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family.
  
 0.977
ACS41918.1
Putative branched-chain amino acid aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
  
 
0.922
ACS42657.1
Putative branched-chain amino acid aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
  
 
0.921
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase, pantothenate biosynthetic process; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
    
 0.920
ACS40808.1
Putative cystathionine gamma-synthase, PLP-dependent (metB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
   
 0.916
ilvA
Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.901
gshA
Gamma-glutamylcysteine synthetase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.
     
  0.900
hom
Homoserine dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.882
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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