node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS38751.1 | dfrA | MexAM1_META1p0830 | MexAM1_META1p2852 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.963 |
ACS38751.1 | fmt | MexAM1_META1p0830 | MexAM1_META1p1529 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.970 |
ACS38751.1 | folC | MexAM1_META1p0830 | MexAM1_META1p4888 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Bifunctional folylpolyglutamate synthase and dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | 0.722 |
ACS38751.1 | ftfL | MexAM1_META1p0830 | MexAM1_META1p0329 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | 0.466 |
ACS38751.1 | gcvT | MexAM1_META1p0830 | MexAM1_META1p0622 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Function of strongly homologous gene; enzyme. | 0.962 |
ACS38751.1 | glyA | MexAM1_META1p0830 | MexAM1_META1p3384 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.948 |
ACS38751.1 | metH | MexAM1_META1p0830 | MexAM1_META1p1494 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.924 |
ACS38751.1 | purH | MexAM1_META1p0830 | MexAM1_META1p2535 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Bifunctional: IMP cyclohydrolase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.722 |
ACS38751.1 | purN | MexAM1_META1p0830 | MexAM1_META1p2044 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.967 |
ACS38751.1 | thyA | MexAM1_META1p0830 | MexAM1_META1p2853 | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.816 |
dfrA | ACS38751.1 | MexAM1_META1p2852 | MexAM1_META1p0830 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Putative Formyl transferase (fmt-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.963 |
dfrA | fmt | MexAM1_META1p2852 | MexAM1_META1p1529 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.967 |
dfrA | folC | MexAM1_META1p2852 | MexAM1_META1p4888 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional folylpolyglutamate synthase and dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | 0.956 |
dfrA | ftfL | MexAM1_META1p2852 | MexAM1_META1p0329 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | 0.944 |
dfrA | gcvT | MexAM1_META1p2852 | MexAM1_META1p0622 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Function of strongly homologous gene; enzyme. | 0.946 |
dfrA | glyA | MexAM1_META1p2852 | MexAM1_META1p3384 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.929 |
dfrA | metH | MexAM1_META1p2852 | MexAM1_META1p1494 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.922 |
dfrA | purH | MexAM1_META1p2852 | MexAM1_META1p2535 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional: IMP cyclohydrolase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.954 |
dfrA | purN | MexAM1_META1p2852 | MexAM1_META1p2044 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.954 |
dfrA | thyA | MexAM1_META1p2852 | MexAM1_META1p2853 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |