STRINGSTRING
ACS40607.1 ACS40607.1 ACS40629.1 ACS40629.1 ACS38875.1 ACS38875.1 ACS40960.1 ACS40960.1 ACS38333.1 ACS38333.1 thyA thyA dfrA dfrA ACS39791.1 ACS39791.1 ACS40101.1 ACS40101.1 ACS42487.1 ACS42487.1 ACS38245.1 ACS38245.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACS40607.1Hypothetical protein; No homology to any previously reported sequences. (289 aa)    
Predicted Functional Partners:
ACS40629.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
  
 0.863
ACS38875.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
    0.778
ACS40960.1
Conserved hypothetical protein, DUF1624; Homologs of previously reported genes of unknown function.
  
    0.778
ACS38333.1
Putative ABC transporter, fused tandem ATPase and permease domains; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.
  
  
 0.611
thyA
Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.607
dfrA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
       0.592
ACS39791.1
Putative cob(II)yrinic acid a,c-diamide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
  
 0.581
ACS40101.1
Nitroreductase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
  
 0.581
ACS42487.1
Putative oxidoreductase protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
  
 0.581
ACS38245.1
Putative ABC-2 transporter, permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.
   
  
 0.561
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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