node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS40667.1 | ACS40668.1 | MexAM1_META1p2915 | MexAM1_META1p2916 | Hypothetical protein; No homology to any previously reported sequences. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.620 |
ACS40667.1 | ACS40670.1 | MexAM1_META1p2915 | MexAM1_META1p2918 | Hypothetical protein; No homology to any previously reported sequences. | MiaB-like tRNA modifying enzyme, putative 2-methylthioadenine synthetase; Function of strongly homologous gene; enzyme. | 0.519 |
ACS40667.1 | ACS41197.1 | MexAM1_META1p2915 | MexAM1_META1p3460 | Hypothetical protein; No homology to any previously reported sequences. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.501 |
ACS40667.1 | ACS41567.1 | MexAM1_META1p2915 | MexAM1_META1p3881 | Hypothetical protein; No homology to any previously reported sequences. | Putative Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.935 |
ACS40667.1 | mutM | MexAM1_META1p2915 | MexAM1_META1p4436 | Hypothetical protein; No homology to any previously reported sequences. | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.643 |
ACS40667.1 | nth | MexAM1_META1p2915 | MexAM1_META1p0411 | Hypothetical protein; No homology to any previously reported sequences. | Endonuclease III DNA glycosylase/apyrimidinic (AP) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.934 |
ACS40667.1 | polA | MexAM1_META1p2915 | MexAM1_META1p2436 | Hypothetical protein; No homology to any previously reported sequences. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.599 |
ACS40667.1 | trpA | MexAM1_META1p2915 | MexAM1_META1p4890 | Hypothetical protein; No homology to any previously reported sequences. | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.476 |
ACS40667.1 | xthA | MexAM1_META1p2915 | MexAM1_META1p1930 | Hypothetical protein; No homology to any previously reported sequences. | Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI); Function of strongly homologous gene; enzyme. | 0.621 |
ACS40667.1 | xthA-2 | MexAM1_META1p2915 | MexAM1_META1p4420 | Hypothetical protein; No homology to any previously reported sequences. | Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI); Function of strongly homologous gene; enzyme. | 0.621 |
ACS40668.1 | ACS40667.1 | MexAM1_META1p2916 | MexAM1_META1p2915 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Hypothetical protein; No homology to any previously reported sequences. | 0.620 |
ACS40668.1 | ACS40670.1 | MexAM1_META1p2916 | MexAM1_META1p2918 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | MiaB-like tRNA modifying enzyme, putative 2-methylthioadenine synthetase; Function of strongly homologous gene; enzyme. | 0.536 |
ACS40670.1 | ACS40667.1 | MexAM1_META1p2918 | MexAM1_META1p2915 | MiaB-like tRNA modifying enzyme, putative 2-methylthioadenine synthetase; Function of strongly homologous gene; enzyme. | Hypothetical protein; No homology to any previously reported sequences. | 0.519 |
ACS40670.1 | ACS40668.1 | MexAM1_META1p2918 | MexAM1_META1p2916 | MiaB-like tRNA modifying enzyme, putative 2-methylthioadenine synthetase; Function of strongly homologous gene; enzyme. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.536 |
ACS41197.1 | ACS40667.1 | MexAM1_META1p3460 | MexAM1_META1p2915 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Hypothetical protein; No homology to any previously reported sequences. | 0.501 |
ACS41567.1 | ACS40667.1 | MexAM1_META1p3881 | MexAM1_META1p2915 | Putative Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Hypothetical protein; No homology to any previously reported sequences. | 0.935 |
ACS41567.1 | mutM | MexAM1_META1p3881 | MexAM1_META1p4436 | Putative Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.651 |
ACS41567.1 | nth | MexAM1_META1p3881 | MexAM1_META1p0411 | Putative Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Endonuclease III DNA glycosylase/apyrimidinic (AP) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.918 |
ACS41567.1 | polA | MexAM1_META1p3881 | MexAM1_META1p2436 | Putative Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.599 |
ACS41567.1 | trpA | MexAM1_META1p3881 | MexAM1_META1p4890 | Putative Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.476 |