node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS40670.1 | dapF | MexAM1_META1p2918 | MexAM1_META1p2917 | MiaB-like tRNA modifying enzyme, putative 2-methylthioadenine synthetase; Function of strongly homologous gene; enzyme. | Diaminopimelate epimerase (DAP epimerase); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.871 |
ACS41365.1 | asdB | MexAM1_META1p3654 | MexAM1_META1p2896 | Putative ornithine/diaminopimelate PLP-dependent decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.700 |
ACS41365.1 | dapA | MexAM1_META1p3654 | MexAM1_META1p3403 | Putative ornithine/diaminopimelate PLP-dependent decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.873 |
ACS41365.1 | dapF | MexAM1_META1p3654 | MexAM1_META1p2917 | Putative ornithine/diaminopimelate PLP-dependent decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Diaminopimelate epimerase (DAP epimerase); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.949 |
ACS41365.1 | lysA | MexAM1_META1p3654 | MexAM1_META1p1718 | Putative ornithine/diaminopimelate PLP-dependent decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.925 |
ACS41365.1 | murE | MexAM1_META1p3654 | MexAM1_META1p5087 | Putative ornithine/diaminopimelate PLP-dependent decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.919 |
asdB | ACS41365.1 | MexAM1_META1p2896 | MexAM1_META1p3654 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Putative ornithine/diaminopimelate PLP-dependent decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.700 |
asdB | dapA | MexAM1_META1p2896 | MexAM1_META1p3403 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.984 |
asdB | dapF | MexAM1_META1p2896 | MexAM1_META1p2917 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Diaminopimelate epimerase (DAP epimerase); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.876 |
asdB | gltB | MexAM1_META1p2896 | MexAM1_META1p3477 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Glutamate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.772 |
asdB | lysA | MexAM1_META1p2896 | MexAM1_META1p1718 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.587 |
asdB | murE | MexAM1_META1p2896 | MexAM1_META1p5087 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.426 |
carB | dapF | MexAM1_META1p0858 | MexAM1_META1p2917 | Carbamoyl phosphate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarB family. | Diaminopimelate epimerase (DAP epimerase); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.912 |
carB | gltB | MexAM1_META1p0858 | MexAM1_META1p3477 | Carbamoyl phosphate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarB family. | Glutamate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.969 |
dapA | ACS41365.1 | MexAM1_META1p3403 | MexAM1_META1p3654 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Putative ornithine/diaminopimelate PLP-dependent decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.873 |
dapA | asdB | MexAM1_META1p3403 | MexAM1_META1p2896 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.984 |
dapA | dapF | MexAM1_META1p3403 | MexAM1_META1p2917 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Diaminopimelate epimerase (DAP epimerase); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.681 |
dapA | lysA | MexAM1_META1p3403 | MexAM1_META1p1718 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.898 |
dapE | dapF | MexAM1_META1p1527 | MexAM1_META1p2917 | N-succinyl-diaminopimelate deacylase (dapE); Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | Diaminopimelate epimerase (DAP epimerase); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.932 |
dapE | rppH | MexAM1_META1p1527 | MexAM1_META1p2285 | N-succinyl-diaminopimelate deacylase (dapE); Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.475 |