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pntAB pntAB pntAA pntAA pntB pntB ppnK ppnK nadE nadE cobB-2 cobB-2 nadD nadD mazG mazG ACS42500.1 ACS42500.1 dkgA dkgA gshA gshA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
pntABNAD(P) transhydrogenase, subunit alpha part 2; Function of strongly homologous gene; enzyme. (150 aa)    
Predicted Functional Partners:
pntAA
NAD(P)+ transhydrogenase, subunit alpha part 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.999
pntB
NAD(P) transhydrogenase, subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
 0.999
ppnK
Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
     
 0.920
nadE
NAD(+) synthase (glutamine-hydrolyzing) with a nitrilase-like domain; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
     
 0.910
cobB-2
NAD-dependent protein deacetylase, regulatory protein SIR2 family; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the sirtuin family. Class III subfamily.
     
 0.909
nadD
Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
     
 0.908
mazG
Nucleoside triphosphate pyrophosphohydrolase MazG; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
  0.900
ACS42500.1
Putative nucleotide pyrophosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
     
  0.900
dkgA
2,5-diketo-D-gluconate reductase A; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
      
 0.697
gshA
Gamma-glutamylcysteine synthetase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.
   
  
 0.688
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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