node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
eno | guaA | MexAM1_META1p2984 | MexAM1_META1p3135 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.430 |
eno | queF | MexAM1_META1p2984 | MexAM1_META1p2983 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | GTP cyclohydrolase family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.483 |
exsB | ptpS | MexAM1_META1p1010 | MexAM1_META1p1009 | Putative regulator, ATP-binding; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Putative 6-pyruvol tetrahydrobiopterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.988 |
exsB | queA | MexAM1_META1p1010 | MexAM1_META1p3283 | Putative regulator, ATP-binding; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase (Queuosine biosynthesis protein queA); Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.456 |
exsB | queE | MexAM1_META1p1010 | MexAM1_META1p1004 | Putative regulator, ATP-binding; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.996 |
exsB | queF | MexAM1_META1p1010 | MexAM1_META1p2983 | Putative regulator, ATP-binding; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | GTP cyclohydrolase family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.994 |
exsB | ribAB | MexAM1_META1p1010 | MexAM1_META1p3198 | Putative regulator, ATP-binding; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.425 |
grxC | queF | MexAM1_META1p3489 | MexAM1_META1p2983 | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | GTP cyclohydrolase family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.565 |
guaA | eno | MexAM1_META1p3135 | MexAM1_META1p2984 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.430 |
guaA | ptpS | MexAM1_META1p3135 | MexAM1_META1p1009 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Putative 6-pyruvol tetrahydrobiopterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.462 |
guaA | queE | MexAM1_META1p3135 | MexAM1_META1p1004 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.489 |
guaA | queF | MexAM1_META1p3135 | MexAM1_META1p2983 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | GTP cyclohydrolase family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.490 |
guaA | ribAB | MexAM1_META1p3135 | MexAM1_META1p3198 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.652 |
guaA | ribD | MexAM1_META1p3135 | MexAM1_META1p3381 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.558 |
guaA | tgt | MexAM1_META1p3135 | MexAM1_META1p3285 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Queuine tRNA-ribosyltransferase (tRNA-guanine transglycosylase) (Guanine insertion enzyme); Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowi [...] | 0.796 |
ptpS | exsB | MexAM1_META1p1009 | MexAM1_META1p1010 | Putative 6-pyruvol tetrahydrobiopterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Putative regulator, ATP-binding; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.988 |
ptpS | guaA | MexAM1_META1p1009 | MexAM1_META1p3135 | Putative 6-pyruvol tetrahydrobiopterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.462 |
ptpS | queE | MexAM1_META1p1009 | MexAM1_META1p1004 | Putative 6-pyruvol tetrahydrobiopterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.994 |
ptpS | queF | MexAM1_META1p1009 | MexAM1_META1p2983 | Putative 6-pyruvol tetrahydrobiopterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | GTP cyclohydrolase family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.904 |
queA | exsB | MexAM1_META1p3283 | MexAM1_META1p1010 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase (Queuosine biosynthesis protein queA); Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Putative regulator, ATP-binding; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.456 |