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pdhC pdhC lpd lpd pdhA pdhA pdhB pdhB lpd-2 lpd-2 ACS42101.1 ACS42101.1 sucA sucA gltA gltA sucC sucC sucD sucD leuA leuA
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pdhCDihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (470 aa)    
Predicted Functional Partners:
lpd
Dihydrolipoyl dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 0.999
pdhA
Pyruvate dehydrogenase E1 alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.999
pdhB
Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
0.999
lpd-2
Dihydrolipoamide dehydrogenase, E3 Component of Pyruvate dehydrogenase multienzyme complex; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 0.999
ACS42101.1
Putative dihydrolipoamide dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 0.992
sucA
2-oxoglutarate dehydrogenase complex, E1 component, 2-oxoglutarate decarboxylase, thiamine binding; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 0.980
gltA
Citrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family.
  
 0.974
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.963
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.960
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
     
 0.947
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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